Journal List > J Korean Rheum Assoc > v.17(3) > 1003737

J Korean Rheum Assoc. 2010 Sep;17(3):272-277. Korean.
Published online September 30, 2010.
Copyright © 2010 The Korean Rheumatism Association
A Case of Cutaneous Leukocytoclastic Vasculitis Presenting as the First Symptom of Adenosquamous Carcinoma of the Lung
Hyun-Ok Kim,1,4 Ho Cheol Kim,1,4 Gyung Hyuck Ko,2,4 Inseok Jang,3,4 Min Gyu Kang,1 Hyun Oh Park,3 Jian Hur,5 and Sang-Il Lee1,4
1Department of Internal Medicine, Gyeongsang National University School of Medicine, Jinju, Korea.
2Department of Pathology, Gyeongsang National University School of Medicine, Jinju, Korea.
3Department of Chest Surgery, Gyeongsang National University School of Medicine, Jinju, Korea.
4Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, Korea.
5Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Corresponding author (Email: )
Received March 18, 2010; Revised April 16, 2010; Accepted April 20, 2010.


Leukocytoclastic vasculitis (LV) is a systemic inflammatory disorder involving the small vessels. The exact cause of LV remains unknown, yet malignancy has been considered as a causative factor for LV. We experienced a 60-year-old male with purpura on his extremities. Computed tomography of the chest showed a mass lesion that was suspected to be a non-small-cell lung cancer and the biopsy revealed an adenosquamous carcinoma. There has been no report of LV associated with adenosquamous carcinoma of the lung in Korea. Thus, we report here on this case along with a review of the relevant articles.

Keywords: Leukocytoclastic vasculitis; Lung cancer; Adenosquamous carcinoma


Fig. 1
Purpuric lesions on the lower extremities.
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Fig. 2
(A) Chest PA shows fibrotic change with calcification in the right lung apical area and calcified pleural plaque in the left lower lung zone as the sequela of pulmonary tuberculosis. (B) Contrast enhanced CT shows about a 2 cm sized heterogeneous low attenuating mass lesion in the right lower lobe (posterior to the liver dome) (arrow).
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Fig. 3
(A) The dermal small vessels show swelling of the endothelial cells. The outline of the blood vessels appears indistinct due to the infiltration of inflammatory cells around the blood vessels (arrow). The infiltrate consists mainly of neutrophils and a small number of eosinophils and mononuclear cells. There is fragmentation of nuclei (leukocytoclasis) (dotted arrow). (B) The lung cancer shows components of both squamous cell carcinoma (arrow) and adenocarcinoma (dotted arrow) (Hematoxylin-Eosin Stain, A ×400, B ×100).
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Table 1
Cases of leukocytoclastic vasculitis with malignancy
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