A Case of Disseminated Crytococcosis in a Patient with Systemic Lupus Erythematosus

Hye Ryun Jung; Hyun Hee Kwon; Jung-Yoon Choe

doi:10.4078/jkra.2010.17.2.194

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Jung, Kwon, and Choe: A Case of Disseminated Crytococcosis in a Patient with Systemic Lupus Erythematosus

Original Article

J Korean Rheum Assoc 2010;17(2):194-199.

Published online: 23 June 2010

DOI: https://doi.org/10.4078/jkra.2010.17.2.194

A Case of Disseminated Crytococcosis in a Patient with Systemic Lupus Erythematosus

Hye Ryun Jung¹, Hyun Hee Kwon¹, Jung-Yoon Choe^1,²

¹Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Daegu, Korea

²Arthritis and Autoimmunity Research Center, Catholic University of Daegu, Daegu, Korea

Received 29 September 200922 December 2009 Accepted 6 January 2010

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Disseminated cryptococcosis mainly occurs in immunocompromised patients. It enters the body through the respiratory tract and spreads to the lungs, skin, liver and lymphoid organs. Among cryptococcosis, cryptococcal meningitis is a relatively frequent manifestation and causes serious morbidity and mortality. It needs urgent diagnosis and initiation of effective antifungal therapy. It is difficult to differentiate cryptococcal meningitis from neuropsychiatric lupus due to similar clinical symptoms, laboratory and cerebrospinal fluid findings. We report a case of disseminated cyrptococcosis in a patient with systemic lupus erythematosus being managed with mycophenolate mofetil, prednisolone and hydroxychloroquine.

Keywords: Disseminated cryptococcosis, Systemic lupus erythematosus

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