The Efficacy and Safety of Leflunomide in the Treatment of Rheumatoid Arthritis

Jung-Yoon Choe

doi:10.4078/jkra.2009.16.2.71

Journal List > J Korean Rheum Assoc > v.16(2) > 1003705

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Choe: The Efficacy and Safety of Leflunomide in the Treatment of Rheumatoid Arthritis

Original Article

J Korean Rheum Assoc 2009;16(2):71-73.

Published online: 20 June 2009

DOI: https://doi.org/10.4078/jkra.2009.16.2.71

The Efficacy and Safety of Leflunomide in the Treatment of Rheumatoid Arthritis

Jung-Yoon Choe

Department of Internal Medicine, Catholic University of Daegu, School of Medicine, Daegu, Korea

Received 1 June 2009 Revised 5 June 2009 Accepted 5 June 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

References

1. American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines. Guidelines for the management of rheumatoid arthritis: 2002 Update. Arthritis Rheum. 2002; 46:328–46.

2. Park YB, Lee SK. Leflunomide; a new disease modifying antirheumatic drug. J Korean Rheum Assoc. 2000; 7:323–32.

3. Saag KG, Teng GG, Patkar NM, anuntiyo J, Finney C, Curtis JR, et al. American College of Rheumatology 2008 Recommendations for the use of nonbiologic and biologic disease-modifying antirheumatic drugs in rheumatoid arthritis. Arthritis Rheum. 2008; 59:762–84.

4. Chang JH, Jung ES, Lee JH, Yoon BY, Lee CH, Lee YW. Hepatotoxicity of combination treatment with leflunomide and methotrexate in RA patients. J Korean Rheum Assoc. 2009; 16:16–22.

5. Chung SH, Kim HJ, Kim SH, Kim CG, Hwang IS, Choe JY. Combination treatment with leflunomide and methotrexate in patients with rheumatoid arthritis: the efficacy, safety, and predisposing factors for treatment response. Korean J Med. 2005; 69:10–20.

6. Ju JH, Kim SI, Lee JH, Lee SI, Yoo WH, Choe JY, et al. Risk of interstitial lung disease associated with leflunomide treatment in Korean patients with rheumatoid arthritis. Arthritis Rheum. 2007; 56:2094–6.

7. Lee SS, Park YW, Park JJ, Kang YM, Nam EJ, Kim SI, et al. Combination treatment with leflunomide and methotrexate for patients with active rheumatoid arthritis. Scand J Rheumatol. 2009; 38:11–4.

8. Strand V, Cohen S, Schiff M, Weaver A, Fleischmann R, Cannon G, et al. Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med. 1999; 159:2542–50.

9. Kremer JM, Genovese MC, Cannon GW, Caldwell JR, Cush JJ, Furst DE, et al. Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate. Ann Intern Med. 2002; 137:726–33.

10. Curtis JR, Beukelman T, Onofrei A, Cassell S, Greenberg JD, Kavanaugh A, et al. Elevated liver enzyme tests among rheumatoid arthritis and psoriatic arthritis patients treated with methotrexate and/or leflunomide. Ann Rheum Dis 2009 Jan 15 [Epub ahead of print].

TOOLS

Similar articles