Journal List > J Korean Rheum Assoc > v.16(4) > 1003687

Ha, Jung, Lee, Choi, Lee, Lee, and Park: A Case of Dermatomyositis Showing Vesicular Lesion Associated with Ovarian Cancer

Abstract

Dermatomyositis is a rare inflammatory myopathy with characteristic skin manifestations and accompanied by muscular weakness. Vesicle formation in dermatomyositis is rare. We report a case of dermatomyositis associated with ovarian cancer in a 62-year-old woman who had vesicles and bullae on her arms. She had erythema and edema on the face, chest, abdomen, and shoulder for 2 months. Diagnosis of dermatomyositis was established by clinical manifestations, muscle enzyme elevation, and a characteristic electromyogram. She was successfully treated with cyclosporin and high doses of steroids.

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Fig. 1.
Skin lesions (A) periorbital erythema and edema (Heliotrope rash), (B, C) diffuse erythematous swelling on the anterior chest, neck, upper back and shoulder (V sign, Shawl sign) (D) multiple erythematous patches and bullae on the right arm.
jkra-16-291f1.tif
Fig. 2.
Skin biopsy revealed subepidermal inflammatory bullae (A) epidermal atrophy and marked subepidermal edema (H&E stain, ×40), (B) inflammatory cell (lymphocyte, histiocyte, and eosinophil) infiltration around the bullae. (H&E stain, ×200).
jkra-16-291f2.tif
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