Renal Artery Thrombosis in a Patient with Systemic Lupus Erythematosus without Antiphospholipid Antibody Syndrome: A Case Study

Dong Gu Kang; Bong Soo Kim; Eun Hee Jang; Sang Yop Shin; Jinseok Kim

doi:10.4078/jkra.2009.16.3.248

Journal List > J Korean Rheum Assoc > v.16(3) > 1003680

Go to TopGo to Top Go to BottomGo to Bottom

TOOLS

Kang, Kim, Jang, Shin, and Kim: Renal Artery Thrombosis in a Patient with Systemic Lupus Erythematosus without Antiphospholipid Antibody Syndrome: A Case Study

Original Article

J Korean Rheum Assoc 2009;16(3):248-252.

Published online: 20 September 2009

DOI: https://doi.org/10.4078/jkra.2009.16.3.248

Renal Artery Thrombosis in a Patient with Systemic Lupus Erythematosus without Antiphospholipid Antibody Syndrome: A Case Study

Dong Gu Kang¹, Bong Soo Kim², Eun Hee Jang¹, Sang Yop Shin¹, Jinseok Kim¹

¹Department of Internal Medicine, College of Medicine, Jeju National University, Jeju, Korea

²Department of Radiology, College of Medicine, Jeju National University, Jeju, Korea

Received 7 May 2009 Revised 9 July 2009 Accepted 10 July 2009

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic lupus erythematosus (SLE) is a multisystemic inflammatory autoimmune disease caused by various autoantibodies and immune complexes. SLE and antiphospholipid antibodies are associated with thrombotic manifestations. However, renal artery thrombosis which causes renal artery occlusion is uncommon even in SLE patients with antiphospholipid antibodies. A 27-year-old woman with SLE suddenly developed left flank pain and generalized edema. From the laboratory workup, the woman was negative for antiphospholipid antibody and nephrotic-range proteinuria was detected. Computed tomography revealed renal artery thromboembolism and multiple renal infarctions with parenchymal perfusion defects in the left kidney. Renal biopsy showed WHO classification III and V lupus nephritis. Left flank pain, generalized edema and proteinuria were resolved and the thromboembolism resolved itself after a high dose of steroid and anticoagulation therapy. In SLE patients, sudden onset of unexplained flank pain is considered as a possible symptom of renal vessel thromboembolism even if the antiphospholipid antibody is negative.

Keywords: Systemic lupus erythematosus, Antiphospholipid antibodies, Renal infarction

References

1. Mok CC, Tang SS, To CH, Petri M. Incidence and risk factors of thromboembolism in systemic lupus erythematosus: a comparison of three ethnic groups. Arthritis Rheum. 2005; 52:2774–82.

2. Appel GB, Pirani CL, D'Agati V. Renal vascular complications of systemic lupus erythematosus. J Am Soc Nephrol. 1994; 4:1499–515.

3. Frostegard J. SLE, atherosclerosis and cardiovascular disease. J Intern Med. 2005; 257:485–95.

4. Tsugawa K, Tanaka H, Kudo M, Nakahata T. Renal artery thrombosis in a pediatric case of systemic lupus erythematosus without antiphospholipid antibodies. Pediatr Nephrol. 2005; 20:1648–50.

5. Suwabe H, Moriuchi J, Hoshina Y. Renal and cerebral infarctions in a patient with systemic lupus erythematosus without antiphospholipid antibodies. Ryumachi. 1993; 33:335–40.

6. Hall S, Buettner H, Luthra HS. Occlusive retinal vascular disease in systemic lupus erythematosus. J Rheumatol. 1984; 11:846–50.

7. Nikpour M, Urowitz MB, Gladman DD. Premature atherosclerosis in systemic lupus erythematosus. Rheum Dis Clin North Am. 2005; 31:329–54.

8. Asherson RA, Derksen RH, Harris EN, Bouma BN, Gharavi AE, Kater L, et al. Chorea in systemic lupus erythematosus and "lupus-like" disease: association with antiphospholipid antibodies. Semin Arthritis Rheum. 1987; 16:253–9.

9. Hernandez D, Dominquez ML, Diaz F, Fernandez ML, Lorenzo V, Rodriquez A, et al. Renal infarction in a severely hypertensive patient with lupus erythematosus and antiphospholipid antibodies. Nephron. 1996; 72:298–301.

10. Laskin CA, Clark CA, Spitzer KA. Antiphospholipid syndrome in systemic lupus erythematosus: is the whole greater than the sum of its parts? Rheum Dis Clin North Am. 2005; 31:255–72.

11. Soltesz P, Veres K, Lakos G, Kiss E, Muszbek L, Szeqedi G. Evaluation of clinical and laboratory features of antiphospholipid syndrome: a retrospective study of 637 patients. Lupus. 2003; 12:302–7.

12. Raij L, Shultz PJ. Endothelium-derived relaxing factor, nitric oxide: effects on and production by mesangial cells and the glomerulus. J Am Soc Nephrol. 1993; 3:1435–41.

13. Ross R. Atherosclerosis–an inflammatory disease. N Engl J Med. 1999; 340:115–26.

Fig. 1.

27-year-old woman with multiple left renal infarctions. (A) Contrast-enhanced computed tomography image during corticomedullary phase shows multiple parenchymal perfusion defects in the left kidney compatible with renal infarctions. Multiple filling defects (arrows) in left main and segmental renal arteries suggest the thromboembolism. (B) Follow-up contrast-enhanced maximal intensity projection image obtained one week later shows the thromboembolism is no longer present in the left main and segmental renal arteries as well as a decreased extent of parenchymal loss.

Fig. 2.

27-year-old woman with lupus nephritis WHO class III+V. (A) Light microscopy shows moderate hypercellular mesangial tissue and focal endocapillary proliferation. Capillary loops are focally thickened with subendothelial deposition (H&E stain, ×400). (B) Electron microscopy shows diffuse effacement of epithelial foot processes and wide spread subepithelial electron-dense deposition (×5,000).

Table 1.

Comparison of previous renal infarction cases of SLE patients negative for antiphospholipid antibodies to the current case

	A^∗	B^†	C^‡
Sex	Male	Female	Female
Race	Asian	Asian	Asian
Age	13-year old	42-year-old	27-year-old
SLE duration	11-month	8-year	4-year
Symptom	Hypertension, fever, seizure, abdominal pain	Right abdominal pain	Left flank pain, generalized edema
Drug history	Prednisolone, mizoribine, dilazep dihydrochloride	Prednisolone, azathioprine	Prednisolone, hydroxychloroquine
Other complication	CNS lupus, lupus nephritis	Lupus nephritis	Lupus nephritis

^∗ Tsugawa K, Tanaka H, Kudo M, Nakahata T. Renal artery thrombosis in a pediatric case of systemic lupus

^† Suwabe H, Moriuchi J, erythematosus without antiphospholipid antibodies. Pediatr Nephrol 2005; 20(11):1648–50., Hoshina Y. Renal and cerebral infarctions in a patient with systemic lupus erythematosus without antiphospholipid antibodies. Ryumachi 1993;33(4):335–40.,

^‡ Current case

TOOLS

Similar articles