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Abstract
Cytomegalovirus (CMV) infection commonly affects patients who are in an immunocompromised state, such as acquired immune deficiency syndrome (AIDS) and during organ transplantation. Although cytomegalovirus infection does not occur frequently, it is a major cause of morbidity and mortality in patients suffering with connective tissue diseases, including dermatomyositis. Cytomegalovirus pneumonitis and retinitis has been rarely reported in patients with dermatomyositis. We report here on an usual case involving the simultaneous occurrence of cytomegalovirus pneumonitis and retinitis in a 39-year-old female with dermatomyositis, and this woman had been treated with steroids and immunosuppressive agents for the previous 5 months.
References
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Fig. 1.
Chest CT shows a cavitary lesion (4.1×4.0 cm) with a thin wall and internal septation at the subpleural region of the right lower lobe.
Fig. 2.
The fundoscopic examination shows retinal whitening and vascular sheathings, and these findings are consistent with CMV retinitis.
Fig. 3.
The thoracoscopic lung biopsy specimen shows chronic inflammation with marked aggregations of foamy and epithelioid macrophages in the lung parenchyme (H & E stain, ×100 in A). The immunohistochemistry shows CMV antigen positive cells (note the brown colored cell in the center of the figure) (immunohistochemical stain for CMV antigen, ×100 in B).
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