A Case of Systemic Lupus Erythematosus Patient with Ulcerative Colitis

Kyeong A Lee; Sang-Cheol Bae; So Young Bang; Won Jun Kim; Hye Young Kim; Chang Nam Son; Oh Young Lee; Seung Sam Paik

doi:10.4078/jkra.2008.15.2.328

Journal List > J Korean Rheum Assoc > v.15(4) > 1003642

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Lee, Bae, Bang, Kim, Kim, Son, Lee, and Paik: A Case of Systemic Lupus Erythematosus Patient with Ulcerative Colitis

Original Article

J Korean Rheum Assoc 2008;15(4):328-331.

Published online: 20 January 2008

DOI: https://doi.org/10.4078/jkra.2008.15.2.328

A Case of Systemic Lupus Erythematosus Patient with Ulcerative Colitis

Kyeong A Lee¹, Sang-Cheol Bae¹, So Young Bang¹, Won Jun Kim¹, Hye Young Kim¹, Chang Nam Son¹, Oh Young Lee², Seung Sam Paik³

¹Department of Internal Medicine, Hanyang Univercity, Division of Rheumatology, Seoul, Korea

²Department of Internal Medicine, The Hospital for Rheumatic Diseases, Division of Gatroenterology, Department of Internal Medicine, Seoul, Korea

³Department of Pathology, Hanyang University College of Medicine, Seoul, Korea

Received 2 September 2008 Accepted 26 September 2008

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Systemic lupus erythematosus (SLE) and ulcerative colitis (UC) are both considered as systemic diseases with an abnormal immune response that depends on interactions between susceptibility genes and environmental factors. Patients with UC may share common manifestations with SLE, for example peripheral arthritis, oral ulcer. Although many autoimmune disorders tend to coexist in one patient, these two diseases are rarely associated with each other. We reported a case of a 36-year-old female where rectal bleeding was identified as ulcerative colitis. She was diagnosed as SLE prior to ulcerative colitis. There are no documented reports on SLE with ulcerative colitis in Korea.

Keywords: Systemic lupus erythematosus, Ulcerative colitis, Inflammatory bowel disease

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Fig. 1.

Colonoscopic findings. Lost of vascular markings is observed and aphthous ulcers and friability are shown (A). After 6 weeks of treatment, there has been a significant improvement (B).

Fig. 2.

Microscopic finding. The rectal mucosa shows heavy inflammatory infiltration in the lamina propria (A) and aphtous ulcer (B) with severe goblet cell depletion (H&E stain, ×200).

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