Journal List > J Korean Rheum Assoc > v.14(1) > 1003601

Choi, Choe, Lee, Seo, Park, Kim, Park, and Shin: Remission of Refractory Intestinal Behcet's Disease with Infliximab

Abstract

Behcet's disease is a chronic, relapsing vasculitis of unknown origin that affects nearly all organs. The most frequent extra-oral sites of gastrointestinal involvement are the ileocecal lesion and the colon. The lesions are typically resistant to medical treatment and frequently recur with surgical treatment. We describe a patient who had intestinal Behcet's disease complicated perforation and enterocutanous fistula with a good response to infliximab.

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Fig. 1.
Resected right colon showed marked serosal adhesion with peritonitis. The mucosal surface of the one segment shows multifocal ulcers with many deep fissure formation.
jkra-14-61f1.tif
Fig. 2.
Ulcerative lesions are typically sharply demarcated from the adjacent mucosa and have mucosal collarettes (H&E stain, X100).
jkra-14-61f2.tif
Fig. 3.
Colonoscopic examination showed a large deep- penetrating ulcer with elevated nodular margin in the anastomotic site.
jkra-14-61f3.tif
Fig. 4.
One month (A) and six month (B) after the first infliximab injection, follow-up colonoscopic examination showed improvement of the ulcer.
jkra-14-61f4.tif
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