Journal List > J Korean Rheum Assoc > v.14(4) > 1003591

Yi, Lee, Son, Kim, Lee, Kang, Choi, Park, Park, and Lee: Two Cases of Calcinosis Cutis Combined with Rheumatologie Disease

Abstract

The calcinosis, dystrophic soft tissue calcification, occurs in damaged or devitalized tissues normal calcium/phosphorus metabolism. It is the subcutaneous tissues of connective tissues disease - primarily systemic lupus erythematosus, scleroderma, or dermatomyositis - and may involve a relatively localized area. The calcinotic accumulations may result in muscle atrophy, joint contractures, and skin ulceration complicated by recurrent episodes of local inflammation and infection. Calcinosis may be the source of both pain and disability in connective tissue disease patients. While various therapeutic modality have been used, no treatment has convincingly prevented or reduced calcinosis. We report two cases of calcinosis cutis combined with rheumatic disease.

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Fig. 1.
Abdomen-pelvis CT at diagnosis, Case 1. There are extensive calcifications and fascial thickening involving left side abdominal wall, subcutaneous layer predominantly.
jkra-14-395f1.tif
Fig. 2.
Microscopic findings showing fat necrosis with calcification (H&E stain x 40) (A) and vacuolar interface dermatitis with necrotic keratinocytes (H&E stain∗200) (B). Case 1.
jkra-14-395f2.tif
Fig. 3.
Abdomen-pelvis CT showed extensive calcification involving gluteal area, subcutaneous layer predominantly. Case 2.
jkra-14-395f3.tif
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