Journal List > J Korean Rheum Assoc > v.14(4) > 1003591

J Korean Rheum Assoc. 2007 Dec;14(4):395-400. Korean.
Published online December 31, 2007.
Copyright © 2007 The Korean Rheumatism Association
Two Cases of Calcinosis Cutis Combined with Rheumatologic Disease
Seung Woo Yi, M.D., Sang Won Lee, M.D., Myoung Kyun Son, M.D., Yu Jin Kim, M.D., Kwang Hoon Lee, M.D., Eun Jin Kang, M.D., Sang Tae Choi, M.D., Min Chan Park, M.D., Yong Beom Park, M.D. and Soo Kon Lee, M.D.
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Received June 20, 2007; Accepted August 16, 2007.


The calcinosis, dystrophic soft tissue calcification, occurs in damaged or devitalized tissues normal calcium/phosphorus metabolism. It is the subcutaneous tissues of connective tissues disease ??primarily systemic lupus erythematosus, scleroderma, or dermatomyositis ??and may involve a relatively localized area. The calcinotic accumulations may result in muscle atrophy, joint contractures, and skin ulceration complicated by recurrent episodes of local inflammation and infection. Calcinosis may be the source of both pain and disability in connective tissue disease patients. While various therapeutic modality have been used, no treatment has convincingly prevented or reduced calcinosis. We report two cases of calcinosis cutis combined with rheumatic disease.

Keywords: Calcinosis cutis; Dystrophic calcification; Rheumatic disease


Fig. 1
Abdomen-pelvis CT at diagnosis, Case 1. There are extensive calcifications and fascial thickening involving left side abdominal wall, subcutaneous layer predominantly.
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Fig. 2
Microscopic findings showing fat necrosis with calcification (H&E stain ×40) (A) and vacuolar interface dermatitis with necrotic keratinocytes (H&E stain×200) (B). Case 1.
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Fig. 3
Abdomen-pelvis CT showed extensive calcification involving gluteal area, subcutaneous layer predominantly. Case 2.
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