Journal List > J Korean Rheum Assoc > v.14(4) > 1003585

Ko, Seo, Lee, Jang, Kim, and Lee: Overlap Syndrome of Amyopathic Antisynthetase Syndrome and Systemic Lupus Erythematosus: A Case Report

Abstract

Interstitial lung disease (ILD) with autoantibodies against antisynthetase may occur in the absence of clinically apparent myositis. We report 58-year-old woman who initially presented with dyspnea. The patient showed positive immunologic markers reflecting systemic lupus erythematosus, destructive polyarthritis, Raynaud's phenomenon, and ILD. There is no proximal muscle weakness in her symptoms. This syndrome was confirmed by positive antibodies to Jo-1. For the early diagnosis of this syndrome, the possibility of this syndrome including other connective tissue disease should be considered in patients presenting with symptoms related to ILD and positive anti-nuclear antibody.

REFERENCES

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Fig. 1.
Shortening of digits with deformity of distal interphalangeal joints was showed on both hands.
jkra-14-363f1.tif
Fig. 2.
Simple radiographs of both hands show that periarticular osteopenia, joint space narrowing, erosion with destruction in both distal interphalangeal joints.
jkra-14-363f2.tif
Fig. 3.
Plain radiography of chest (A) and high resolution computed tomography of lung (B) demonstrate interstitial infiltrates, bullae and the honeycombing appearance on whole lung fields.
jkra-14-363f3.tif
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