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Abstract
Interstitial lung disease (ILD) with autoantibodies against antisynthetase may occur in the absence of clinically apparent myositis. We report 58-year-old woman who initially presented with dyspnea. The patient showed positive immunologic markers reflecting systemic lupus erythematosus, destructive polyarthritis, Raynaud's phenomenon, and ILD. There is no proximal muscle weakness in her symptoms. This syndrome was confirmed by positive antibodies to Jo-1. For the early diagnosis of this syndrome, the possibility of this syndrome including other connective tissue disease should be considered in patients presenting with symptoms related to ILD and positive anti-nuclear antibody.
REFERENCES
1). 김채규: 유대현: 송용호: 정자헌: 노성민: 오영배등. 특징적인Mechanic's hand 를동반한antisynthetase 증후군2예. 대한류마티스학회지. 1999. 6:178–84.
2). Imbert-Masseau A., Hamidou M., Agard C., Grolleau JY., Cherin P. Antisynthetase syndrome. Joint Bone Spine. 2003. 70:161–8.
3). Nishikai M., Reichlin M. Heterogeneity of precipitating antibodies in polymyositis and dermatomyositis. Characterization of the Jo-1 antibody system. Arthritis Rheum. 1980. 23:881–8.
4). Friedman AW., Targoff IN., Arnett FC. Interstitial lung disease with autoantibodies against aminoacyl-tRNA synthetases in the absence of clinically apparent myositis. Semin Arthritis Rheum. 1996. 26:459–67.
5). Delbrel X., Schaeverbeke T., Lifermann F., Dehais J. Arthropathy associated with anti-Jo-1 antibody. Joint Bone Spine. 2001. 68:166–9.
6). Sauty A., Rochat T., Schoch OD., Hamacher J., Kurt AM., Dayer JM, et al. Pulmonary fibrosis with predominant CD8 lymphocytic alveolitis and anti-Jo-1 antibodies. Eur Respir J. 1997. 10:2907–12.
7). Plastiras SC., Soliotis FC., Vlachoyiannopoulos P., Tzelepis GE. Interstitial lung disease in a patient with antisynthetase syndrome and no myositis. Clin Rheumatol. 2007. 26:108–11.
8). Vazquez-Abad D., Rothfield NF. Sensitivity and specificity of anti-Jo-1 antibodies in autoimmune diseases with myositis. Arthritis Rheum. 1996. 39:292–6.
9). Ramos-Casals M., Brito-Zeron P. Font J. The overlap of Sjogren's syndrome with other systemic autoimmune diseases. Semin Arthritis Rheum. 2007. 36:246–55.
10). Ramos-Casals M., Nardi N., Brito-Zeron P., Aguilo S., Gil V., Delgado G, et al. Atypical autoantibodies in patients with primary Sjogren syndrome: clinical characteristics and follow-up of 82 cases. Semin Arthritis Rheum. 2006. 35:312–21.
11). Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic erythematosus. Arthritis Rheum. 1997. 40:1725.
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