Journal List > J Korean Rheum Assoc > v.14(3) > 1003568

Choi, Park, Lee, Ryu, Lee, Lee, Lee, and Song: A Case of Ankylosing Spondylitis Accompanying Sarcoidosis

Abstract

Sacroiliitis is a rare manifestation in patients with sarcoidosis and there have been several case reports of ankylosing spondylitis (AS) accompanying sarcoidosis. Recently, the development of sarcoidosis has been reported in AS patients treated with tumor necrosis factor blocker. We described a 27-year-old male patient with AS and histologically proven sarcoidosis who was treated with etanercept without aggravation of sarcoidosis.

REFERENCES

1). Pettersson T. Rheumatic features of sarcoidosis. Curr Opin Rheumatol. 1998. 10:73–8.
crossref
2). Griep EN., van Spiegel PI., van Soesbergen RM. Sarcoidosis accompanied by pulmonary tuberculosis and complicated by sacroiliitis. Arthritis Rheum. 1993. 36:716–21.
crossref
3). Kotter I., Durk H., Saal JG. Sacroiliitis in sarcoidosis: case reports and review of the literature. Clin Rheumatol. 1995. 14:695–700.
crossref
4). Franco M., Passeron C., Tieulie N., Verdier JF., Benisvy D. Long-term radiographic follow-up in a patient with osteosclerotic sarcoidosis of the spine and pelvis. Rev Rhum Engl Ed. 1998. 65:586–90.
5). Stucki G., Von Felten A., Speich R., Michel BA. Ankylosing spondylitis and sarcoidosis: coincidence or association-Case report and review of the literature. Clin Rheumatol. 1992. 11:436–9.
6). 김동순: 안종준. 한국의유육종증발생현황. 결핵및호흡기질환. 2000. 49:274–80.
7). Lofgren. S Primary sarcoidosis. Acta Med scand. 1953. 145:424–31.
8). Erb N., Cushley MJ., Kassimos DG., Shave RM., Kitas GD. An assessment of back pain and the prevalence of sacroiliitis in sarcoidosis. Chest. 2005. 127:192–6.
crossref
9). Van der Linden S., Valkenbrug HA., Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. Aproposal for modification of the New York criteria. Arthritis Rheum. 1984. 27:361–8.
10). Gonzalez-Lopez MA., Blanco R., Gonzalez-Vela MC., Fernandez-Llaca H., Rodriguez-Valverde V. Development of sarcoidosis during etanercept therapy. Arthritis Rheum. 2006. 55:817–20.
crossref
11). Hunninghake GW., Crystal RG. Pulmonary sarcoidosis: a disorder mediated by excess helper T-lymphocyte activity at sites of disease activity. N Engl J Med. 1981. 305:429–34.
12). Rudwaleit M., Siegert S., Yin Z., Eick J., Thiel A., Radbruch A, et al. Low T cell production of TNFa and IFNg in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism. Ann Rheum Dis. 2001. 60:36–42.
13). Rudwaleit M., Andermann B., Alten R., Sorensen H., Listing J., Zink A, et al. Atopic disorders in ankylosing spondylitis and rheumatoid arthritis. Ann Rheum Dis. 2002. 61:968–74.
crossref

Fig. 1.
Chest CT shows bilateral mediastinal lymphadeno pathy without lung parenchymal involvement.
jkra-14-251f1.tif
Fig. 2.
Pelvis AP shows bilateral sacroiliitis, grade 3.
jkra-14-251f2.tif
Fig. 3.
Pathologic finding of hilar lymph node (H&E stain, x400) shows non-caseating granuloma. it was negative for acid fast bacilli (AFB) stain and tuberculosis polymerase chain reaction (PCR).
jkra-14-251f3.tif
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