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Abstract
Objective:
To identify the sensitivity and specificity of the anti-cyclic citrullinated peptide antibody (anti-CCP) and rheumatoid factor (RF) in a diagnosis of Korean early rheumatoid arthritis (RA).
Methods:
Two hundred and sixty two patients diagnosed with RA were examined retrospectively and classified by three groups. A group 1 had a disease duration <24 months, and group 2 had a duration>24 months, and the third was a group of total patients. The sensitivity and specificity of the RF and anti-CCP in each group of RA were identified. Patients of the connective tissue disease other than rheumatoid arthritis were tested with RF and anti-CCP.
Results:
The sensitivity/specificity of RF and the anti-CCP in early RA were 90.4%/68.0% and 87.5%/89.3%, 91.3%/68.0%, 81.7%/89.3% in each, and 90.4%/68.0% and 84.7%/89.3% in the total RA patients. The accurate diagnosis rate, which is defined as (number of true positives plus true negatives)/ the total number of patients), of the RF and anti-CCP was 79.2%/88.4% in the early RA group, and 79.4% and 89.0% in the total patients group.
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Fig. 1.
Receiver operator characteristics (ROC) curves of RF and anti-CCP. (A) RA <24 Mo, (B) RA >24 Mo, (C) RA total.
Table 1.
Baseline characteristics of studied patients
∗Two sample t-test between male and female age
Other connective tissue disease : 3 Adult onset Still's disease, 8 Behçet's disease, 26 Fibromyalgia syndrome, 9 Gout, 4 Juvenile rheumatoid arthritis, 4 Mixed connective tissue disease, 2 Polymyalgia rheumatica, 51 Palindromic rheumatism, 3 Psoriatic arthritis, 3 Systemic lupus erythematosus, 1 Systemic sclerosis, 8 Undifferentiated connective tissue Disease
Table 2.
Comparison of laboratory parameters in each group of patients
∗Diseases that can show RF positivity
AOSD: Adult onset Still's disease, BD: Behçet's disease, FMS: Fibromyalgia syndrome, JRA: Juvenile rheumatoid arthritis, PMR: Polymyalgia rheumatica, PR: Palindromic rheumatism, PsA: Psoriatic arthritis, SLE: Systemic lupus erythematosus, SSc: Systemic sclerosis, MCTD: Mixed connective tissue disease, UCTD: Undifferentiated connective tissue Disease
Table 3.
Comparison of laboratory parameters in each group of RA patients
Table 4.
Positive rate of RF and anti-CCP antibody in each group of RA patients
Table 5.
Sensitivities, specificities and accurate diagnosis rate of RF and CCP Ab in each group of RA patients
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