Journal List > J Korean Endocr Soc > v.24(2) > 1003487

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Lee, Roh, Yoo, Han, Nam, Cho, Park, Ahn, and Kim: A Case of Pseudohypoparathyroidism without Albright's Hereditary Osteodystrophy in an Adult
Case Report
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2009; 24(2): 132-137.

Published online: 30 June 2009

DOI: https://doi.org/10.3803/jkes.2009.24.2.132

A Case of Pseudohypoparathyroidism without Albright's Hereditary Osteodystrophy in an Adult

Yoonbum Lee, Jungmin Roh, Jeong seon Yoo, Jeongwoo Han, Jisun Nam, Minho Cho, Jongsuk Park, Chulwoo Ahn, Kyungrae Kim

Department of Internal Medicine, Yonsei University of College of Medicine, Korea.

Received 24 November 2008       Accepted 10 May 2009

Copyright © 2009 Korean Endocrine Society

Abstract

Pseudohypoparathyroidism is a rare disease caused by resistance to parathyroid hormone, and is associated with typical clinical typical symptoms such as tetany and seizures, hypocalcemia, hyperphosphatemia and increased parathyroid hormone levels. Pseudohypoparathyroidism is classified to Type Ia, Ib, Ic and II according to the clinical and biochemical manifestations. Type Ia and Ic have morphological characteristics called Albright's hereditary osteodystrophy. Type Ib differs from type II for the pathogenesis. Type Ib may~receptors and type II may~ pathway, but the pathophysiology of type II is not clear yet. Administration of parathyroid hormone extract may help to distinguish between the two types. We report a case of a pseudohypoparathyroidism type Ib or II patient who had tetany, hypocalcemia and hyperphosphatemia with normal morphologic features.

Keywords: hypocalcemia, pseudohypoparathyroidism

Figures and Tables

Fig. 1
The contour of patient's face. No gross abnormality.
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Fig. 2
A. The contour of patient's hand. No gross abnormality. B. The contour of patient's hand. No gross abnormality.
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Fig. 3
Brain CT image. Symmetric high attenuation is noted in the basal ganglia and dentate nucleus suggesting calcification.
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Fig. 4
Electroencephalography (EEG). EEG shows normal pattern.
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Fig. 5
Both hand AP image. No gross bony abnormality.
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