Journal List > J Korean Endocr Soc > v.23(5) > 1003461

Jun, Lee, Kim, Lee, and Chang: Primary Hypogonadism Associated with Ankylosing Spondylitis


Male patients with hypogonadism have an increased risk of developing rheumatic diseases. Most causes of hypogonadism related with rheumatic disease are karyotype abnormality such as Klinefelter's syndrome or Turner's syndrome and gonadal dysgenesis. A 24-year-old year male was admitted for pain of both hip joints that had worsened over 2 months. He had hip joint involvement from ankylosing spondylitis and did not show secondary sex characteristics. His sex hormones and gonadotropins levels indicated hypergonadotropic hypogonadism. The karyotype was 46 XY, and there was no obvious cause of hypogonadism. Here we report on clinical features of this first Korean case of primary hypogonadism accompanying ankylosing spondylitis.

Figures and Tables

Fig. 1
Clinical feature of the patient. He showed obese build and gynecomastia, axillary hair loss, genu valgum and he had a small penis and scrotums.
Fig. 2
X-ray test of hip joint. Marginal erosive change with sclerosis at acetabular side of both hip joint is noted with mild space narrowing.
Fig. 3
T2-weighted magnetic resonance images through the sacroiliac joints. Arrows showed enhancement at the both sacroiliac joints, indicating active sacroiliitis.
Fig. 4
Sonography of testes. Too small testes are noted (Lt. 1.3 × 0.5 cm, Rt. 1.5 × 0.5 cm) and subcutaneous fat is very thick.


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