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Nam, Cho, Roh, Kim, Yoon, Jung, Park, Kang, Ahn, Cha, Lee, Lim, Kim, and Lee: A Case of Turner's Syndrome with Transient Hypopituitarism
Case Report
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2007; 22(4): 266-271.

Published online: 20 August 2007

DOI: https://doi.org/10.3803/jkes.2007.22.4.266

A Case of Turner's Syndrome with Transient Hypopituitarism

Ji Sun Nam, Min Ho Cho, Jung Min Roh, Hai Jin Kim, Ji Eun Yoon, Han Young Jung, Jong Suk Park, Eun Seok Kang, Chul Woo Ahn, Bong Soo Cha, Eun Jig Lee, Sung Kil Lim, Kyung Rae Kim, Hyun Chul Lee

Department of Internal Medicine, Yonsei Universitiy College of Medicine, Korea.

Received 19 March 2007       Accepted 29 May 2007

Copyright © 2007 Korean Endocrine Society

Abstract

Turner's syndrome is characterized by short stature and gonadal dysgenesis, and it is often associated with various systemic manifestations, such as cardiovascular, renal, thyroidal, gastrointestinal, and musculoskeletal disorders. Though very rare, it can also be accompanied by hypopituitarism. It is important to give a meticulous medical attention to short females with gonadal dysgenesis so that neither disease is neglected or gets delayed diagnosis. In this case, Turner's syndrome and hypopituitarism were diagnosed almost simultaneously, but hypopiuitarism was transient, and the normal pituitary function was recovered spontaneously without any treatment. Initial sella MRI showed mild congenital hypoplastic hypopituitarism, and combined pituitary function test was compatible with hypopituitarism, but after 5 years, though growth hormone deficiency was still present, otherwise normal pituitary function was noted without any change in MRI. Herein, we are reporting a case of Turner's syndrome with transient idiopathic hypopituitarism with the review of literature.

Keywords: Growth hormone deficiency, Transient hypopituitarism, Turner's syndrome

Figures and Tables

Fig. 1
The patient has karyotype of 45,X/46,XX.
jkes-22-266-g001
Fig. 2
Sella dynamic MRI (2001.4.8). Mild, diffuse shrinkage of pituitary gland with slightly upward displacement and reduced size of neurohypophysis is seen, compatible with congenital hypoplasitc hypopituitarism.
jkes-22-266-g002
Fig. 3
Sella dynamic MRI (2006.10.13). No remarkable interval change of pituitary gland size and shape on this study. Mild hypoplastic pituitary gland is suggested.
jkes-22-266-g003
Table 1
Combined pituitary function test (2001. 4. 6)
jkes-22-266-i001

ACTH < 5.1 pg/mL, T3 92.9 ng/dL, fT4 1.1 ng/dL, IGF-I 136.6 ng/mL, insulin 3.0 U/mL, estradiol 85.5 pg/mL. GH, Growth hormone; LH, Luteinizing hormone; FSH, follicle-stimulating hormone; TSH, thyroid stimulating hormone.

Table 2
Follow-up combined pituitary function test (2006. 10.12)
jkes-22-266-i002

ACTH < 5.1 pg/mL, T3 114.5 ng/dL, fT4 1.3 ng/dL, IGF-I 103 ng/mL, insulin 3.4 IL/ml, estradiol 12.5 pg/mL.

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