Journal List > J Korean Endocr Soc > v.22(4) > 1003373

Nam, Cho, Roh, Kim, Yoon, Jung, Park, Kang, Ahn, Cha, Lee, Lim, Kim, and Lee: A Case of Turner's Syndrome with Transient Hypopituitarism


Turner's syndrome is characterized by short stature and gonadal dysgenesis, and it is often associated with various systemic manifestations, such as cardiovascular, renal, thyroidal, gastrointestinal, and musculoskeletal disorders. Though very rare, it can also be accompanied by hypopituitarism. It is important to give a meticulous medical attention to short females with gonadal dysgenesis so that neither disease is neglected or gets delayed diagnosis. In this case, Turner's syndrome and hypopituitarism were diagnosed almost simultaneously, but hypopiuitarism was transient, and the normal pituitary function was recovered spontaneously without any treatment. Initial sella MRI showed mild congenital hypoplastic hypopituitarism, and combined pituitary function test was compatible with hypopituitarism, but after 5 years, though growth hormone deficiency was still present, otherwise normal pituitary function was noted without any change in MRI. Herein, we are reporting a case of Turner's syndrome with transient idiopathic hypopituitarism with the review of literature.

Figures and Tables

Fig. 1
The patient has karyotype of 45,X/46,XX.
Fig. 2
Sella dynamic MRI (2001.4.8). Mild, diffuse shrinkage of pituitary gland with slightly upward displacement and reduced size of neurohypophysis is seen, compatible with congenital hypoplasitc hypopituitarism.
Fig. 3
Sella dynamic MRI (2006.10.13). No remarkable interval change of pituitary gland size and shape on this study. Mild hypoplastic pituitary gland is suggested.
Table 1
Combined pituitary function test (2001. 4. 6)

ACTH < 5.1 pg/mL, T3 92.9 ng/dL, fT4 1.1 ng/dL, IGF-I 136.6 ng/mL, insulin 3.0 U/mL, estradiol 85.5 pg/mL. GH, Growth hormone; LH, Luteinizing hormone; FSH, follicle-stimulating hormone; TSH, thyroid stimulating hormone.

Table 2
Follow-up combined pituitary function test (2006. 10.12)

ACTH < 5.1 pg/mL, T3 114.5 ng/dL, fT4 1.3 ng/dL, IGF-I 103 ng/mL, insulin 3.4 IL/ml, estradiol 12.5 pg/mL.


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