Journal List > J Korean Endocr Soc > v.22(2) > 1003353

Joo, Park, Moon, Kang, Ihm, Choi, Yoo, Lee, Oh, and Park: A Case of Kallmann's Syndrome Mildly Presenting as Secondary Amenorrhea

Abstract

Kallmann's syndrome is very rare congenital defect in GnRH (gonadotrophin releasing hormone) secretion involving both sexes. The mode of inheritance has not been fully understood. But, including X-linked inheritance, the ratio of incidence between male versus female is 5:1, and there is a few case reports of female Kallmann's syndrome in Korea, especially in internal medicine department. We report a case of 35 year-old female Kallmann's syndrome presenting secondary amenorrhea as a mild presentation.

Figures and Tables

Fig. 1
Olfactory MRI - Coronal Section (A-T1, B-T2 image).
Both olfactory bulbs are not visualized. Right side olfactory sulcus is not noted and left side olfactory sulcus (A, B- arrow) is also hypoplastic. There is no demonstrable other abnormality in subfrontal brain, and sino-nasal cavity.
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Table 1
Combined pituitary stimulation test
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T3 120.9 ng/dL, free T4 1.06 ng/dL

E2 9.83 pg/mL, free testosterone 0.04 pg/mL, testosterone 0.1 ng/mL

IGF-1 271 ng/mL

ACTH, Adrenocorticotropic Hormone; E2, estradiol; FSH, Follicle-stimulating hormone; GH, Growth Hormone; IGF-1, Insulin-like Growth Factor-1; LH, Luteinizing hormone; PRL, Prolactin; TSH, Thyroid Stimulating Hormone; T3, Triiodothyronine; T4, Thyroxine.

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