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Abstract
Kallmann's syndrome is very rare congenital defect in GnRH (gonadotrophin releasing hormone) secretion involving both sexes. The mode of inheritance has not been fully understood. But, including X-linked inheritance, the ratio of incidence between male versus female is 5:1, and there is a few case reports of female Kallmann's syndrome in Korea, especially in internal medicine department. We report a case of 35 year-old female Kallmann's syndrome presenting secondary amenorrhea as a mild presentation.
Figures and Tables
Fig. 1
Olfactory MRI - Coronal Section (A-T1, B-T2 image).
Both olfactory bulbs are not visualized. Right side olfactory sulcus is not noted and left side olfactory sulcus (A, B- arrow) is also hypoplastic. There is no demonstrable other abnormality in subfrontal brain,
and sino-nasal cavity.
Table 1
Combined pituitary stimulation test
T3 120.9 ng/dL, free T4 1.06 ng/dL
E2 9.83 pg/mL, free testosterone 0.04 pg/mL, testosterone 0.1 ng/mL
IGF-1 271 ng/mL
ACTH, Adrenocorticotropic Hormone; E2, estradiol; FSH, Follicle-stimulating hormone; GH, Growth Hormone; IGF-1, Insulin-like Growth Factor-1; LH, Luteinizing hormone; PRL, Prolactin; TSH, Thyroid Stimulating Hormone; T3, Triiodothyronine; T4, Thyroxine.
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