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Ma, Kim, Nam, Jung, Yu, Lee, Park, and Lim: Effect of Weight Loss on Endothelial Function in Obese Premenopausal Women
Original Article
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2006; 21(6): 506-514.

Published online: 20 December 2006

DOI: https://doi.org/10.3803/jkes.2006.21.6.506

Effect of Weight Loss on Endothelial Function in Obese Premenopausal Women

Se Woong Ma, Se Hwa Kim1, Hyo Sung Nam, Kee Myoung Jung, Byung Hyun Yu, Yong Ju Lee, Seok O Park, Sung Kil Lim1

Department of Internal Medicine, Gwangmyung Sung-Ae General Hospital, Korea.

1Department of Internal Medicine, Yonsei University College of Medicine, Korea.

Received 18 October 2006       Accepted 1 December 2006

Copyright © 2006 Korean Endocrine Society

Abstract

Background

Endothelial dysfunction, a pathological feature of obesity, can predict the occurrence of cardiovascular disease. The endothelial function was compared in obese, non-obese, and type 2 diabetic women, and the effect of weight loss on endothelial function in obese premenopausal women was also investigated.

Methods

Twenty type 2 diabetes patients, 35 obese and 20 non-obese non-diabetic subjects were recruited. Both the endothelium-dependent vasodilation (EDV) and endothelium-independent vasodilation (EIV) were measured. The body composition, serum lipid, serum adiponectin and resistin were also measured. Weight loss in obese women was obtained by 6 months of calorific restriction, aerobic exercise and medication (sibutramine or orlistat).

Results

EDV was significantly impaired in the type 2 diabetes and obese groups compared to the control group (6.0 ± 1.3% in diabetes group, 6.7 ± 3.9% in obese group, 12.4 ± 4.1% in control group, P < 0.01, respectively). The mean weight loss after 6 months was 8.5 ± 3.2 kg (P < 0.001) in the obese group. There was a significant increase in EDV after weight loss (from 5.8 ± 3.5% to 12.3 ± 3.9%, P < 0.05). There was no change in EIV after weight loss. In addition, weight loss was associated with significant reductions in the levels of high-sensitivity C-reactive protein (hs-CRP) and serum triglyceride (P < 0.05, respectively). However, there were no significant changes in the serum adiponectin and resistin levels after weight loss.

Conclusions

Our data demonstrated that weight loss was associated with improved endothelial function in obese premenopausal women, as assessed by brachial artery EDV and reduced hs-CRP

Keywords: Adipocytokine, Endothelium-dependent vasodilation, Endothelium-independent vasodilation, Obesity, Weight loss

Figures and Tables

Fig. 1
Baseline serum adiponectin (A) and resistin (B) concentration in non-obese, obese and diabetic women. Results are expressed as the mean ± SD. *P < 0.01; †P < 0.05.
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Fig. 2
Endothelium-dependent (A) and endothelium-independent (B) vasodilation in non-obese, obese and diabetic women. EDV, endothelium-dependent vasodiation; EIV, endothelium-independent vasodilation. *P < 0.01.
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Fig. 3
Effect of weight loss in endothelial function of obese women. EDV, endothelium-dependent vasodilation; EIV, endothelium-independent vasodilation. *P < 0.05.
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Table 1
Baseline characteristics of study subjects
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All data are expressed as the mean ± SD except hs-CRP which is presented as mean ± SE.

*P < 0.01 vs. non-obese women.

†P < 0.05 vs. obese women.

DBP, diastolic blood pressure; HOMA-IR, homeostasis model assessment of insulin resistance; hs-CRP, high sensitivity C-reactive protein; SBP, systolic blood pressure; VSR, visceral fat vs. subcutaneous fat area ratio.

Table 2
Effects of weight loss in anthropometric and metabolic variables of 13 obese women
jkes-21-506-i002

Results are expressed as the mean ± SD.

*hs-CRP is logarithmically transformed before analysis and is presented as mean ± SE.

DBP, diastolic blood pressure; HOMA-IR, homeostasis model assessment of insulin resistance; hs-CRP, high sensitivity C-reactive protein; SBP, systolic blood pressure.

Table 3
Bivariate regression analysis of endothelium-dependent vasodilation improvement on anthropometric and metabolic factors
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