Journal List > J Korean Endocr Soc > v.21(6) > 1003332

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Koh, Rhee, Kim, Jung, Park, Lee, Oh, Park, and Kim: The Relationship between Lumbar Spine Bone Mineral Density and Cardiovascular Risk Factors in Korean Female Adults
Original Article
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2006; 21(6): 497-505.

Published online: 20 December 2006

DOI: https://doi.org/10.3803/jkes.2006.21.6.497

The Relationship between Lumbar Spine Bone Mineral Density and Cardiovascular Risk Factors in Korean Female Adults

Young-Yul Koh, Eun-Jung Rhee, Se-Yeon Kim1, Chan-Hi Jung, Cheol-Young Park, Won-Young Lee, Ki-Won Oh, Sung-Woo Park, Sun-Woo Kim

Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea.

1Institute of Medical Science, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Korea.

Received 27 June 2006       Accepted 10 October 2006

Copyright © 2006 Korean Endocrine Society

Abstract

Background

Recent studies suggest a possible pathogenic linkage between the osteoporosis and atherosclerosis. We investigated the relationship between cardiovascular risk factors, including high sensitivity C-reactive protein (hs-CRP), insulin resistance, lipid profiles and bone metabolism in Korean females.

Methods

Anthropometric measurements were performed on 437 women (mean age 52 yrs), and cardiovascular risk factors, including fasting blood glucose, fasting blood insulin, lipid profiles and hs-CRP, measured. An atherogenic index was calculated using the serum total cholesterol level divided by the high-density lipoprotein cholesterol (HDL-C) level. The lumbar spine bone mineral density (BMD) was measured using dual X-ray absorptiometry

Results

From bivariate analyses, the lumbar spine BMD showed negative correlations with age, systolic and diastolic blood pressures, serum total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglyceride levels and atherogenic index, and a positive correlation with the HDL-C level. After adjustment for age and BMI, the atherogenic index and HDL-C showed consistent correlation with the lumbar spine BMD. The log-transformed hs-CRP showed no correlation with the lumbar spine BMD. In premenopausal women, age, BMI and atherogenic index showed significant associations with the lumbar spine BMD and the atherogenic index showed consistently significant correlation, even after adjustment for age and BMI. In postmenopausal women, only age and BMI showed significant correlations with the lumbar spine BMD. From multiple linear regression analyses of all the study subjects, age, BMI, atherogenic index and the presence of menopause were found to be determinants of the lumbar spine BMD (R2 = 0.422, p < 0.05), which was consistently significant in analysis performed on premenopausal women (R2 = 0.157, P < 0.05). In postmenopausal women, age and BMI were found to be the determinants of the lumbar spine BMD (R2 = 0.257, P < 0.05).

Conclusions

The lumbar spine BMD was negatively correlated with the atherogenic index in all and in premenopausal women. The menopause seems to play an important role in the relationship of cardiovascular risk factors with BMD in Korean females.

Keywords: Atherosclerosis, High-sensitivity C-reactive protein, Lipid profiles, Lumbar spine bone mineral density

Figures and Tables

Table 1
Clinical characteristics of the study subjects
jkes-21-497-i001

HOMA-IR, homeostatic model assessment-insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hs-CRP, high sensitivity C-reactive protein; BMD, bone mineral density.

*P < 0.05 in comparison analyses of mean values vs. presmenopausal women.

†Atherogenic index was calculated with total cholesterol level divided by HDL-C.

Table 2
Correlation analyses between cardiovascular risk factors and lumbar spine BMD in Korean females according to menopausal status
jkes-21-497-i002

BMD, bone mineral density; HOMA-IR, homeostatic model assessment-insulin resistance; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; hs-CRP, high-sensitivity C-reactive protein; log (hs-CRP), log-transformed hs-CRP.

*P < 0.05 in bivariate correlation analyses between lumbar spine BMD and cardiovascular risk factors.

†P < 0.05 in partial correlation analyses after adjustment for age and BMI.

Table 3
Multiple regression analysis with lumbar spine BMD as the dependent variable
jkes-21-497-i003

BMD, bone mineral density; HOMA-IR, homeostasis model index-insulin resistance; hs-CRP, high-sensitivity C-reactive protein.

R2 = 0.422.

Table 4
Multiple regression analysis with lumbar spine BMD as the dependent variable in premenopausal women
jkes-21-497-i004

BMD, bone mineral density; HOMA-IR, homeostasis model index-insulin resistance; hs-CRP, high-sensitivity C-reactive protein.

R2 = 0.157.

Table 5
Multiple regression analysis with lumbar spine BMD as the dependent variable in postmenopausal women
jkes-21-497-i005

BMD, bone mineral density; HOMA-IR, homeostasis model index-insulin resistance; hs-CRP, high-sensitivity C-reactive protein.

R2 = 0.273.

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