Journal List > J Korean Endocr Soc > v.21(5) > 1003325

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Park, Ahn, Kang, Won, Lee, Kim, Mok, Park, Kim, Kim, Byun, Suh, and Yoo: A Case of Primary Hypothyroidism with Anti-Triiodothyronine Autoantibody
Case Report
Journal of Korean Endocrine Society

Journal of Korean Endocrine Society 2006; 21(5): 428-432.

Published online: 20 October 2006

DOI: https://doi.org/10.3803/jkes.2006.21.5.428

A Case of Primary Hypothyroidism with Anti-Triiodothyronine Autoantibody

Jae Ho Park, Ji Hoon Ahn, Mi Hee Kang1, Jong Chul Won, Kyung Wook Lee, Yeo Joo Kim, Ji Oh Mok, Hyeong Kyu Park, Chul Hee Kim, Sang Jin Kim, Dong Won Byun, Kyo Il Suh, Myung Hi Yoo

Department of Internal Medicine, SoonChunHyang University Hospital, Korea.

1Institute of Endocrinology Research,SoonChunHyang University Hospital, Korea.

Received 25 July 2006       Accepted 25 August 2006

Copyright © 2006 Korean Endocrine Society

Abstract

Antithyroid hormone autoantibodies can be present in the sera of patients with thyroid and non-thyroid disorders. Antithyroid hormone autoantibodies in a patient's serum interfere with radioimmunoassay of thyroid hormones. Clinically, this interference can result in discordance between the serum thyroid hormone levels and the clinical features of the patient, which can lead to misdiagnosis or inappropriate treatment. We experienced a woman who had primary hypothyroidism with unexpectedly high concentrations of serum total triiodothyronine (T3) and free T3, and she had been treated for Graves' disease in the past. Through the use of a polyethylene glycol precipitation method, we detected the anti-triiodothyronine autoantibodies in her serum. We report on this case along with a review of the related literature.

Keywords: Anti-triiodothyronine autoantibody, Hypothyroidism

Figures and Tables

Fig. 1
99mTcO4- thyroid scan shows increased uptake of 6.9%.
jkes-21-428-g001
Fig. 2
Percent radioactivity of precipitate in serum by polyethylene glycol.
jkes-21-428-g002

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