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Kim, Lee, Kim, and Oh: Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress
Original Article

Journal of Korean Academy of Nursing 2015; 45(5): 661-670.

Published online: 30 October 2015

DOI: https://doi.org/10.4040/jkan.2015.45.5.661

Disturbance in ADL from Chemotherapy-induced Peripheral Neuropathy and Quality of Life in Cancer Patients: The Mediating Effect of Psychological Distress

Kyung Yeon Kim1, Seung Hee Lee1, Jeong Hye Kim2, Pok Ja Oh3

1Korea Institude of Radiological & Medical Science, Seoul, Korea.

2Department of Clinical Nursing, University of Ulsan, Seoul, Korea.

3Department of Nursing, Sahmyook University, Seoul, Korea.

Address reprint requests to: Oh, Pok-Ja. Department of Nursing, Sahmyook University, 815 Hwarang-ro, Nowon-gu, Seoul 01795, Korea. Tel: +82-2-3399-1589, Fax: +82-2-3399-1594, ohpj@syu.ac.kr

Received 11 February 2015       Revised 17 February 2015       Accepted 5 June 2015

© 2015 Korean Society of Nursing Science

(open-access):

This is an Open Access article distributed under the terms of the Creative Commons Attribution NoDerivs License. (http://creativecommons.org/licenses/by-nd/4.0/) If the original work is properly cited and retained without any modification or reproduction, it can be used and re-distributed in any format and medium.

Abstract

Purpose

The purpose of this study was to examine the mediation of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life in order to provide a basis for planning nursing interventions to improve the quality of life in cancer patients.

Methods

A purposive sample of 130 patients treated with chemotherapy were recruited in the cross-sectional survey design. Data were collected using self-report questionnaires. The instruments were the Chemotherapy Induced Peripheral Neuropathy Assessment Tool (CIPNAT), Hospital Anxiety Depression Scale (HADS), and Functional Assessment of Cancer Therapy-General (FACT-G).

Results

The mean score for disturbance in ADL from chemotherapy induced peripheral neuropathy was 3.30. Overall quality of life was 2.48. The mean score was 1.04 for psychological distress. The prevalence was 35.4% for anxiety and 47.7% for depression. There were significant correlations among the three variables, disturbance in ADL from chemotherapy induced peripheral neuropathy, psychosocial distress, and quality of life. Psychosocial distress had a complete mediating effect (β= -.74, p <.001) in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life (Sobel test: Z= -6.11, p <.001).

Conclusion

Based on the findings of this study, nursing intervention programs focusing on disturbance of ADL management, and decrease of psychological distress are highly recommended to improve quality of life in cancer patients.

Keywords: Quality of life, Peripheral neuropathy, Neoplasm, Depression

Figures and Tables

Figure 1

Mediating effect of psychological distress in the relationship between disturbance in ADL from chemotherapy induced peripheral neuropathy and quality of life.

jkan-45-661-g001
Table 1

Disturbance in ADL, Psychological Distress, and Quality of Life according to General Characteristics of the Participants (N=130)

jkan-45-661-i001

*Vinka-alkaloid, vincristine, velcade; a, b=Scheffé test; CIPN=Chemotherapy-induced peripheral neuropathy.

Table 2

Level of Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Depression, Anxiety, and Quality of Life (N=130)

jkan-45-661-i002

ADL=Activities of daily living.

Table 3

Relationships among Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy, Psychological Distress, and Quality of Life (N=130)

jkan-45-661-i003

ADL=Activities of daily living.

Table 4

Mediating Effect of Psychological Distress in the Relationship between Disturbance in ADL from Chemotherapy induced Peripheral Neuropathy and Quality of Life (N=130)

jkan-45-661-i004

ADL=Activities of daily living; QoL=Quality of life.

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