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Yang and Choe: Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat
Original Article

Journal of Korean Academy of Nursing 2013; 43(3): 361-369.

Published online: 28 June 2013

DOI: https://doi.org/10.4040/jkan.2013.43.3.361

Effect of Anorexia and Neuropathic Pain Induced by Cisplatin on Hindlimb Muscles of Rat

Gee Su Yang1, Myoung-Ae Choe2

1School of Nursing, University of Maryland, Baltimore, MD, U.S.A.

2College of Nursing, Seoul National University, Seoul, Korea.

Address reprint requests to: Yang, Gee Su. School of Nursing, University of Maryland, 655 West Lombard Street, Room 404, Baltimore, MD 21201, U.S.A. Tel: +1-310-424-0756, Fax: +1-410-706-3769, gsyang@umaryland.edu

Received 10 September 2012       Accepted 22 March 2013

© 2013 Korean Society of Nursing Science

Abstract

Purpose

The purpose of this study was to examine the effect of anorexia and neuropathic pain induced by cisplatin on hindlimb muscles of rats.

Methods

Adult male Sprague-Dawley rats were divided into two groups, a cisplatin-treated group (n=10) and a control group (n=10). In the cisplatin-treated group, cisplatin at a dose of 2 mg/kg was injected intraperitoneally two times a week up to a cumulative dose of 20 mg/kg over 5 weeks, and in the control group saline (0.9% NaCl) was injected intraperitoneally at the same dose and duration as the cisplatin-treated group. At 34 days all rats were anesthetized, after which the soleus and plantaris muscles were dissected. Withdrawal threshold, body weight, food intake, activity, muscle weight, Type I and II fiber cross-sectional areas and myofibrillar protein content of the dissected muscles were determined.

Results

Compared with the control group, the cisplatin-treated group showed significant decreases (p<.05) in withdrawal threshold, activity, food intake, body weight, Type I and II fiber cross-sectional areas, myofibrillar protein content and weight of the soleus and plantaris muscles.

Conclusion

Muscular atrophy in hindlimb occurs due to anorexia and neuropathic pain induced by the cisplatin treatment.

Keywords: Cisplatin, Neuropathic pain, Anorexia, Muscular atrophy

Figures and Tables

Figure 1
Changes of withdrawal thresholds in the control and cisplatin groups.
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Table 1
Experimental Procedures
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Table 2
Experimental Results in the Control and Cisplatin Groups
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NP=Neuropathic pain; *Significantly different between the control and cisplatin groups (p<.05).

Notes

This manuscript is based on a part of the first author's master's thesis from Seoul National University.

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