Journal List > J Korean Acad Nurs > v.42(6) > 1002861

Han, Park, Kim, and Kang: Effects of Normal Saline for Maintenance of Arterial Lines of Surgical Patients

Abstract

Purpose

The purpose of this study was to analyze the effectiveness of saline solution vs. heparinized-saline for maintenance of arterial lines and to detect changes in platelet and aPTT as physiological indexes.

Methods

In this nonequivalent control group, non-synchronized, double-blind study the effects of heparinized and saline solution on the maintenance of arterial lines were compared. Fifty five patients received the heparinized solution and fifty nine patients received the saline solution. All patients who had surgery in K-university hospital between September and December 2011 were eligible for participation in the study.

Results

There was no statistically significant difference between the saline and the heparin group in the maintenance time of the arterial lines or the number of irrigations. There was no statistically significant difference between the groups in changes in the number of platelets and aPTT for interaction between the groups and time intervals.

Conclusion

The results indicate that saline solution can be used as an irrigation solution for the maintenance of arterial lines of adult surgical patients, rather than heparinized-saline, in view of potential risk factors in the use of heparin.

Figures and Tables

Table 1
Homogeneity of General Characteristics between Two Groups (N=114)
jkan-42-791-i001

*Fisher's exact test.

ASA=American society of anesthesiologists physical status classification.

Table 2
Homogeneity of Independent Variables between the Two Groups (N=114)
jkan-42-791-i002

aPTT=activated partial thromboplastin time; SBP=Systolic blood pressure; DBP=Diastolic blood pressure.

p<.05.

Table 3
Comparison of Maintenance Time and Number of Flushings of Arterial Lines (N=114)
jkan-42-791-i003

p<.05.

Table 4
Comparison of Change of Platelet & aPTT Counts (N=114)
jkan-42-791-i004

EM=Estimated mean; md=mean difference; aPTT=activated partial thromboplastin time.

p<.05.

References

1. Alexander H. Heparin versus normal saline as a flush solution. Int J Adv Sci Art. 2010. 1(1):63–75.
2. Al-Shaikh B, Stacey S. Essentials of anaesthetic equipment. 2007. 3rd ed. Philadelphia, PA: Churchill Livingstone.
3. Amiral J. Early awareness key to successful management of heparininduce thrombocytopenia. Drugs Ther Perspect. 2001. 17(14):8–12.
4. Aubin B. Arterial lines: A review. Crit Care Q. 1979. 2(2):57–66.
5. Bae JW, Go DH, Chung HJ, Kim TE, Park KD. Heparinized polymer biomaterials. J Korean Ind Eng Chem. 2004. 15(7):693–701.
6. Bedford RF. Long-term radial artery cannulation: Effects on subsequent vessel function. Crit Care Med. 1978. 6(1):64–67. http://dx.doi.org/10.1097/00003246-197801000-00016.
7. Brown JM, Dimeski G. Contamination of coagulation tests with heparin from blood gas samples. Br J Anaesth. 2001. 87(4):628–629. http://dx.doi.org/10.1093/bja/87.4.628.
8. Bucher L. Critical care environment. Medical surgical nursing. 2004. 6th ed. St. Louis, MO: Mosby.
9. Choi SA, Namgung HU, Lee ES, Park DJ, Han HS, Shin WG. Case report: Heparin-induced thrombocytopenia among patients given high nutritive fluid. J Korean Soc Parenter Enter Nutr. 2007. 1(1):38–41.
10. Cook HC. Alternatives to heparin infusion. J Infus Nurs. 2004. 27(6):413–424. http://dx.doi.org/10.1097/00129804-200411000-00007.
11. Del Cotillo M, Grané N, Llavoré M, Quintana S. Heparinized solution vs. saline solution in the maintenance of arterial catheters: A double blind randomized clinical trial. Intensive Care Med. 2008. 34(2):339–343. http://dx.doi.org/10.1007/s00134-007-0886-6.
12. Edmunds MW. Introduction to clinical pharmacology. 2010. 6th ed. Seoul: Chung Moon Gak;399–411.
13. French Society of Anesthesia and Intensive Care. Arterial catheterisation and invasive measurement of arterial blood pressure in anaesthesia and intensive care in adults. Ann Fr Anesth Reanim. 1995. 14(5):444–453. http://dx.doi.org/10.1016/S0750-7658(05)80402-2.
14. Fujita T, Namiki T, Suzuki T, Yamamoto E. Normal saline flushing for maintenance of peripheral intravenous sites. J Clin Nurs. 2006. 15(1):103–104. http://dx.doi.org/10.1111/j.1365-2702.2005.01238.x.
15. Goh LJ, Teo HS, Masagoes M. Heparinized saline versus normal saline in maintaining patency of arterial and central venous catheters. Proc Singap Healthc. 2011. 20(3):190–196.
16. Kaye W. Invasive monitoring techniques: Arterial cannulation, bedside pulmonary artery catheterization and arterial pressure. Heart Lung. 1983. 12(4):395–427.
17. Kim EK. Comparison of the effect of heparinized and nonheparinized flush solution on the patency and maintenance time for arterial lines. 2005. Seoul: Yonsei University;Unpublished master's thesis.
18. Kim SM. Development, application and evaluation of the evidence-based nursing practice guideline for hemodialysis in the patients with risk of bleeding. J Korean Acad Soc Nurs Educ. 2010. 16(1):150–155.
19. Klenner AF, Fusch C, Rakow A, Kadow I, Beyersdorff E, Eichler P, et al. Benefit and risk of heparin for maintaining peripheral venous catheters in neonates: A placebo-controlled trial. J Pediatr. 2003. 143(6):741–745. http://dx.doi.org/10.1016/j.jpeds.2003.09.024.
20. Moon CH, Yeon BR, Kim HJ, Eun BH, Bae YY. Comparison of heparin flushing and normal saline flushing for patency of central catheter in hemato-oncologic patients. Clin Nurs Res. 2006. 11(2):205–213.
21. Paisley MK, Stamper M, Brown J, Brown N, Ganong LH. The use of heparin and normal saline flushes in neonatal intravenous catheters. Pediatr Nurs. 1997. 23(5):521–524. 527
22. Park SY, Bang SO, Kwak YL, Oh YJ, Cho HR, Hong YW. The effect of the radius and longitude of a catheter in continuous arterial blood pressure monitoring. Korean J Anesthesiol. 2002. 43(1):10–14.
23. Silvestri LA. Saunders comprehensive review for the Nclex-RN examination. 2005. 3rd ed. Philadelphia, PA: Elsevier Health Sciences.
24. American Association of Critical-Care Nurses. Evaluation of the effects of heparinized and nonheparinized flush solutions on the patency of arterial pressure monitoring lines: the AACN Thunder Project. Am J Crit Care. 1993. 2(1):3–15.
25. The Korean Society of Anesthesiologists. Anesthesiology & pain medicine. 2010. Seoul: Ryo Moon Gak.
26. Tuncali BE, Kuvaki B, Tuncali B, Capar E. A comparison of the efficacy of heparinized and nonheparinized solutions for maintenance of perioperative radial arterial catheter patency and subsequent occlusion. Anesth Analg. 2005. 100(4):1117–1121. http://dx.doi.org/10.1213/01.ANE.0000146963.19543.D4.
27. Warkentin TE, Greinacher A. Heparin-induced thrombocytopenia and cardiac surgery. Ann Thorac Surg. 2003. 76(2):638–648. http://dx.doi.org/10.1016/S0003-4975(03)00756-2.
28. Whitta RK, Hall KF, Bennetts TM, Welman L, Rawlins P. Comparison of normal or heparinised saline flushing on function of arterial lines. Crit Care Resusc. 2006. 8(3):205–208.
29. Youm W. Heparin-induced thrombocytopenia and thrombosis after coronary artery surgery using extracorporeal circulation. J Soonchunhyang Med Coll. 2004. 10(1):479–484.
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