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Uhm, Nam, Lee, Lee, Yoon, and Chai: Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression
Original Article
Journal of Korean Academy of Nursing

Journal of Korean Academy of Nursing 2012; 42(3): 434-442.

Published online: 29 June 2012

DOI: https://doi.org/10.4040/jkan.2012.42.3.434

Health-related Quality of Life in Korean Patients with Rheumatoid Arthritis: Association with Pain, Disease Activity, Disability in Activities of Daily Living and Depression

Dong Choon Uhm1, Eun Sook Nam2, Ho Yeon Lee3, Eun Bong Lee4, Young Im Yoon5, Gong Ju Chai6

1Assistant Professor, Department of Emergency Medical Technician, Daejeon University, Daejeon, South Korea.

2Professor, Department of Nursing, Health Care Research Center, Kangwon National University, Chuncheon, South Korea.

3Head Nurse, Seoul Medical Center, Seoul, South Korea.

4Professor, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.

5Nurse, Seoul National University Hospital, Seoul, South Korea.

6Nurse, Chuncheon National Hospital, Chuncheon, South Korea.

Address reprint requests to: Nam, Eun Sook. Department of Nursing, Gangwon National University, Hyoja 2(i)-dong, Chuncheon-si, Gangwon-do, SEOUL 200-701 Rep. of KOREA. Tel: +82-33-250-8883, Fax: +82-33-242-8840, esnam7@hanmail.net

Received 7 April 2011       Accepted 30 May 2012

© 2012 Korean Society of Nursing Science

Abstract

Purpose

The purpose of this predictive study was to identify factors affecting health related quality of life (HRQoL) in patients with rheumatoid arthritis (RA).

Methods

The participants in this study were 131 patients with RA who were recruited from the outpatient clinic of a university hospital in Seoul. Disease activity in rheumatoid arthritis was evaluated by calculating the Disease Activity Score 28. Disability in activities of daily living (ADL) was assessed with the Korean Health Assessment Questionnaire, and depression with The Center for Epidemiologic Studies Depression Scale. HRQoL was evaluated using The Short Form 36 Health Survey. Data were analyzed using descriptive statistics, correlation, and hierarchical multiple regression.

Results

Pain, disability in ADL, disease activity, and depression correlated negatively with physical and mental dimensions of HRQoL. But hierachical multiple regression analysis revealed that disability in ADL and depression were the only variables negatively influencing physical and mental QoL after adjustment for influences of sociodemographic variables.

Conclusion

Results of this study suggest that disability in ADL and depression, rather than disease activity and pain have profound effects on HRQoL in patients with RA. Further studies are needed to assess the predictive ability of disease activity and pain on HRQoL in this population.

Keywords: Rheumatoid arthritis, Health related quality of life, Pain, Disability in ADL, Depression

Figures and Tables

Table 1
Health related Quality of Life by Sociodemographic Variables (N=131)
jkan-42-434-i001

QOL=Quality of life.

*p<.05; **p<.01; †The same letters indicate nonsignificant difference between groups based on Tukey's multiple comparison test.

Table 2
Clinical, Psychological Characteristics and Quality of Life (N=131)
jkan-42-434-i002

SD=Standard deviation; RA=Rheumatoid arthritis; ADL=Activities of daily living; KHAQ=Korean health assessment questionnaire; DAS28-ESR= Disease activity score 28-erythrocyte sedimentation rate; VAS=Visual analogue scale; QOL=Quality of life; CES-D=The center for epidemiologic studies-depression scale; SF-36=The medical outcomes study short form 36 health survey.

Table 3
Correlation Coefficients of Study Variables with Physical and Mental QOL (N=131)
jkan-42-434-i003

RA=Rheumatoid arthritis; QOL=Quality of life; ADL=Activities of daily living.

Table 4
Factors Predicting Physical QOL (N=131)
jkan-42-434-i004

a=Dummy coded (married=1, single=0); b=Dummy coded (employed=1, unemployed=0); c=Dummy coded (Catholic or Protestant=1, none or Buddhist=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

Table 5
Factors Predicting Mental QOL (N=131)
jkan-42-434-i005

a=dummy coded (married=1, single=0); b=dummy coded (Catholic or Protestant=1, none or Buddhist=0); c=dummy coded (employed=1, unemployed=0); VAS=Visual analogue scale; QOL=Quality of life; ADL=Activities of daily living; DAS28-ESR=Disease Activity Score 28-Erythrocyte Sedimentation Rate; KHAQ=Korean health assessment questionnaire; RA=Rheumatoid arthritis; CES-D=The Center for Epidemiologic Studies-Depression Scale.

Notes

This work was supported by Kangwon National University, Health care research center in 2011.

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