Journal List > Korean Diabetes J > v.33(6) > 1002340

Chang, Lee, and Lim: The Status of Diabetes Mellitus and Effects of Related Factors on Heart Rate Variability in a Community

Abstract

Background

This study was performed to examine the status of diabetes mellitus (DM) in the community and effects of related factors on heart rate variability (HRV).

Methods

The author conducted HRV testing, a questionnaire survey, and blood chemistry analysis for fasting blood sugar (FBS) and HbA1c levels in 855 patients in a community over a period of 10 days, from August 14 to 25, 2006. The subjects were divided into a DM group and normal group by our study criteria.

Results

The proportion of DM was 12.6% and increased with old age. The mean measures of HRV (SDNN, Tp, Vlf, Lf, Hf, Lf/Hf) in the DM group were 22.7 (1.6) msec, 364.9 (2.7) msec2, 174.1 (3.0) msec2, 88.1 (3.2) msec2, 55.3 (3.2) msec2, and 1.6 (2.6), respectively, while those in the normal group were 32.2 (1.6) msec, 676.6 (2.8) msec2, 295.7 (3.1) msec2, 169.2 (3.4) msec2, 117.2 (3.2) msec2, and 1.4 (2.6), respectively. All parameters except for Lf/Hf were significantly lower in the DM group than in the normal group (P < 0.01). The Spearman's correlation coefficients between HRV and FBS or HbA1c were SDNN -0.222/-0.244 (P < 0.01), Tp -0.211/-0.212 (P < 0.01), Vlf -0.149/-0.132 (P < 0.01), Lf -0.188/-0.235 (P < 0.01), Hf -0.207/-0.204 (P < 0.01), and Lf/Hf (P > 0.05), respectively.

Conclusion

This study shows that the DM group had a reduced HRV and increased pulse rate in comparison with the normal group. According to our results, the HRV test may be used accessorily for the early detection of cardiovascular autonomic neuropathy (CAN) and its related factors, as well as to prevent CAN.

Figures and Tables

Fig. 1
The flow chart of this study.
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Table 1
The comparisons of the factors related to diabetes mellitus between the DM group and normal group
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All values are mean ± standard deviation *P < 0.01 by Student's t test P < 0.05 by Student's t test. DM, diabetes mellitus.

Table 2
The comparisons of the variables related to heart rate variability between the DM group and normal group
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All values are geometric mean (geometric standard deviation). *P < 0.01 by Mann-Whitney U test. DM, diabetes mellitus; Hf, high frequency power; Lf, low frequency power; SDNN, standard deviation of normal to normal intervals; Tp, total power; Vlf, very low frequency power.

Table 3
The comparisons of the variables related to heart rate variability by gender
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All values are geometric mean (geometric standard deviation). *P < 0.01 by Mann-Whitney U test, P < 0.05 by Mann-Whitney U test. Hf, high frequency power; Lf, low frequency power; SDNN, standard deviation of normal to normal intervals; Tp, total power; Vlf, very low frequency power.

Table 4
Correlations between contents related to heart rate variability and factors related to diabetes mellitus
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*P < 0.01 by Spearman's correlation test, P < 0.05 by Spearman's correlation test. BMI, body mass index; BP, blood pressure; FBS, fasting blood sugar; Hf, high frequency power; Lf, low frequency power; SDNN, standard deviation of normal to normal intervals; Tp, total power; Vlf, very low frequency power.

Table 5
The results of multiple regression using the contents related to heart rate variability and its related factors
kdj-33-537-i005

CI, confidence interval; Hf, high frequency power; Lf, low frequency power; SDNN, standard deviation of normal to normal intervals; Tp, total power; Vlf, very low frequency power.

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