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Abstract
Background
The incidence of type 2 diabetes mellitus is increasing annually and patient mortality is high. Coronary artery calcification is a predictor of coronary artery disease. Cardiovascular events, which are the main cause of death in type 2 diabetes patients, may be preventable by addressing risk factors associated with coronary artery calcification. We examined the relationships between coronary artery calcification, lipid profiles, and apolipoprotein levels.
Methods
We calculated the coronary calcium scores (CCS) of 254 subjects with type 2 diabetes (113 males, 141 females) via multi-detector row computed tomography (MDCT). Height, body weight, blood pressure, HbA1c, c-peptide, lipid profile and apolipoprotein were assessed concurrently.
Results
In patients with type 2 diabetes, Agatston score and apolipoprotein A-1 were significantly negatively correlated in both males and females (males P = 0.015, females P = 0.021). The negative correlation between Agatston score and apolipoprotein A-1 was retained for the entire patient sample after adjustments for age and sex (P = 0.022). Stepwise multiple regression anaylses with the Agatston score as the dependent variable indicate that apolipoprotein A-1 is a independent predictor (β coefficient = -0.047, 95%CI = -0.072 ~ -0.021, P < 0.001) of coronary artery calcification.
Figures and Tables
Fig. 1
Negative correlation was seen between Ln (Agatston + 1) and serum apolipoprotein A-1 in females (LnAgatston = Ln (Agatston + 1)).
Fig. 2
Negative correlation was seen between Ln (Agatston + 1) and serum apolipoprotein A-1 in males (LnAgatston = Ln (Agatston + 1)).
Table 1
Basal characteristics in the subjects
*P < 0.05. ACR, urine albumin-creatinine ratio; ApoA1, ApolipoproteinA-1; ApoB, Apolipoprotein B; BMI, body mass index; C-pep, C-peptide level at fasting state; DBP, diastolic blood pressure; FBS, fasting blood sugar; FFA, free fatty acid; HDL, high density lipoprotein; LDL, low density lipoprotein; SBP, systolic blood pressure; T-chol, total cholesterol; TG, triglyceride.
Table 2
Correlations between Ln (Agatston + 1) and biochemical markers in males and females
*P < 0.05. ACR, urine albumin-creatinine ratio; ApoA1, Apolipoprotein A-1; ApoB, Apolipoprotein B; C-pep, C-peptide level at fasting state; FFA, free fatty acid; HDL, high density lipoprotein; hsCRP, high sensitivity C-reactive protein; LDL, low density lipoprotein; T-chol, total cholesterol; TG, triglyceride.
Table 3
Correlations between Ln (Agatston + 1) and biochemical markers in diabetic patients (under age & sex control)
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