The Changes of Central Aortic Pulse Wave Analysis in Metabolic Syndrome

Jee In Lee; Tae Seo Sohn; Hyuk Sang Kwon; Jung Min Lee; Sang Ah Chang; Bong Yun Cha; Hyun Shik Son

doi:10.4093/kdj.2008.32.6.522

Journal List > Korean Diabetes J > v.32(6) > 1002261

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Lee, Sohn, Kwon, Lee, Chang, Cha, and Son: The Changes of Central Aortic Pulse Wave Analysis in Metabolic Syndrome

Original Article

Korean Diabetes Journal

Korean Diabetes Journal 2008; 32(6): 522-528.

Published online: 31 December 2008

DOI: https://doi.org/10.4093/kdj.2008.32.6.522

The Changes of Central Aortic Pulse Wave Analysis in Metabolic Syndrome

Jee In Lee, Tae Seo Sohn, Hyuk Sang Kwon, Jung Min Lee, Sang Ah Chang, Bong Yun Cha, Hyun Shik Son

Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Korea.

Corresponding author: jeein106@naver.com

Received 17 October 2008 Accepted 19 December 2008

Abstract

The metabolic syndrome (MS) has been characterized as a cluster of risk factors that includes dyslipidemia, hypertension, glucose intolerance and central obesity. This syndrome increases the risk of cardiovascular disease. Augmentation index (AIx), a composite of wave reflection form medium-sized muscular arteries is related to the development of coronary artery disease. The aim of this study is to examine the change on central aortic waveforms in subjects between patients with metabolic syndrome and normal subjects. Using the non-invasive technique of pulse wave analysis by applantation tonometry, we investigated central aortic waveforms in 45 patients with MS and 45 matched controls. The MS was defined by NCEP-ATP III criteria. Age did not differ between the two groups. AIx was significantly elevated in patinets with MS compared with controls (21.91 ± 11.41% vs 18.14 ± 11.07%; P < 0.01). Subendocardial viability ratio (SEVR) (158.09 ± 28.69 vs 167.09 ± 30.06; P < 0.01) was significantly decreased in patients with MS compared with controls. Only the fasting glucose (r = 0.317, P = 0.03) among the components of MS and age (r = 0.424, P = 0.004) had a positive correlation with AIx. AIx increased as the number of MS components increased. These results show that the MS increased systemic arterial stiffness. Age and fasting blood glucose are independent risk factors of arterial stiffness in MS. The individual MS components, except for fasting blood glucose, do not affect arterial stiffness independently. But the clustering of MS components might interact to synergistically affect arterial stiffness.

Keywords: Arterial stiffness, Augmentation index, Metabolic syndrome, Pulse wave analysis

Figures and Tables

Fig. 1

Augmentation index according to the number of the components of the metabolic syndrome. ^* P < 0.05.

Table 1

Characteristics of subjects

Data are expressed as means ± SD. HDL, high density lipoprotein; LDL, low density lipoprotein.

Table 2

Central hemodynamic parameters

^* P < 0.01.

Table 3

Univariate correlations for Augmentation index

^* Correlation is significant at the 0.05 level. ^†Correlation is significant at the 0.01 level.

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