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Park: Prevalence and Risk Factors for Mycobacterium tuberculosis Infection among Contacts of Pulmonary Tuberculosis Patients
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2012; 72(2): 140-148.

Published online: 29 February 2012

DOI: https://doi.org/10.4046/trd.2012.72.2.140

Prevalence and Risk Factors for Mycobacterium tuberculosis Infection among Contacts of Pulmonary Tuberculosis Patients

Jae Seuk Park, M.D.

Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.

Address for correspondence: Jae Seuk Park, M.D. Department of Internal Medicine, Dankook University College of Medicine, 16-5, Anseo-dong, Cheonan 330-715, Korea. Phone: 82-41-550-3055, Fax: 82-41-556-3256, jspark@dankook.ac.kr

Received 15 October 2011       Revised 27 November 2011       Accepted 20 December 2011

Copyright © 2012. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

Detection and treatment of tuberculosis (TB) infection with contact investigation is a key component of TB control program. I evaluated the prevalence and risk factors for TB infection among contacts of recently diagnosed pulmonary TB patients in a tertiary hospital in Korea.

Methods

206 contacts of 90 adult pulmonary TB patients underwent tuberculin skin tests (TST) and chest radiography. The TST results were considered positive with an induration of 10 mm or more, suggesting TB infection. A standardized questionnaire was used to assess risk factors associated with TB infection.

Results

TST was positive in 97 of 206 contacts of TB patients (47.1%) and positive rate of TST increased with age. The risk of TB infection was significantly associated with close contact with TB patients (sleeping in the same room) (odd ratio [OR], 4.94; 95% confidence interval [CI], 1.43~17.00).

Conclusion

TB infection rate was higher in the elderly, and the risk of TB infection was significantly increased with close contact of TB patients.

Keywords: Tuberculosis, Contact Tracing, Tuberculin Test

Figures and Tables

Figure 1
Frequencies of TST induration size in contacts (n=206). TST: tuberculin skin test.
trd-72-140-g001
Table 1
Characteristics of the index cases (TB patients) and contacts
trd-72-140-i001

Data are presented as number (%).

BMI: body mass index; Underlying disease: diabetes mellitus.

Table 2
Univariate analysis of risk factors for TB infection among contact characteristics
trd-72-140-i002

OR: odd ratio; CI: confidence interval.

Table 3
Univariate analysis of risk factors for TB infection among contact characteristics (age <35)
trd-72-140-i003

BMI measured only in 68.

BMI: body mass index; OR: odd ratio; CI: confidence interval.

Table 4
Univariate analysis of risk factors for TB infection related to contact exposure to the index case (age <35)
trd-72-140-i004

OR: odd ratio; CI: confidence interval.

Table 5
Univariate analysis of risk factors for TB infection related to index case infectivity (age <35)
trd-72-140-i005

OR: odd ratio; CI: confidence interval.

Table 6
Multivariate analysis of risk factors for TB infection (age <35)
trd-72-140-i006

OR: odd ratio; CI: confidence interval; MA: moderately advanced; FA: far advanced.

Acknowledgments

The present research was conducted by the research fund of Dankook University in 2010.

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