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Song, Lee, Lee, Kim, Lee, Kim, Kim, Yoon, Shin, Park, Choi, Oh, and Sohn: A Case of Small Cell Lung Cancer Coexisting with Chronic Lymphocytic Leukemia
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2011; 71(6): 454-458.

Published online: 29 December 2011

DOI: https://doi.org/10.4046/trd.2011.71.6.454

A Case of Small Cell Lung Cancer Coexisting with Chronic Lymphocytic Leukemia

June Seok Song, M.D.1, Gun Hwa Lee, M.D.1, Min Kyu Lee, M.D.1, Woong Jun Kim, M.D.1, Seung Ho Lee, M.D.1, Sang Heon Kim, M.D., Ph.D.1, Tae Hyung Kim, M.D., Ph.D.1, Ho Joo Yoon, M.D., Ph.D.1, Dong Ho Shin, M.D., Ph.D.1, Sung Soo Park, M.D., Ph.D.1, Jung Hye Choi, M.D., Ph.D.1, Young-Ha Oh, M.D., Ph.D.2, Jang Won Sohn, M.D., Ph.D.1

1Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea.

2Department of Pathology, Hanyang University College of Medicine, Seoul, Korea.

Address for correspondence: Jang Won Sohn, M.D., Ph.D. Department of Internal Medicine, Hanyang University Guri Hospital, 249-1, Gyomun 1-dong, Guri 471-701, Korea. Phone: 82-31-560-2224, Fax: 82-31-555-2998, jwsohn@hanyang.ac.kr

Received 27 May 2011       Accepted 25 July 2011

Copyright © 2011. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia occurring in Western nations. In CLL it is well known that the risk of a secondary malignancy is higher than in the normal population. But in Korea, CLL is a rare type of leukemia, so there have been only a few reported cases with a secondary malignancy. CLL is characterized by progressive defects in both cell-mediated and humoral immunity. It is known that defects in the immune system of patients with CLL contribute to the development of a secondary malignancy. We experienced a case of a 71-year-old man who suffered from a chronic cough and was diagnosed with small cell lung cancer coexisting with CLL. Until this case, there was no reported case in Korea of small cell lung cancer coexisting with CLL. We now report a case of small cell lung cancer coexisting with CLL and present a literature review.

Keywords: Leukemia, Lymphocytic, Chronic, B-Cell, Small Cell Lung Carcinoma

Figures and Tables

Figure 1
The chest x-ray shows right hilar prominence and a consolidative lesion in the right middle lobe territory.
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Figure 2
The chest CT shows a large mass in the right middle lobe subcarinal area. CT: computed tomography.
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Figure 3
(A) The tumor cells show a sheet-like growth pattern with small, oval, round, hyperchromatic nuclei and scant cytoplasm. Nuclear moulding and mitoses are frequent (Hematoxylin-eosin, ×40). (B) The neoplastic cells are positive for synaptophysin immunostaining (×400).
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Figure 4
(A) Bone marrow harboring monomorphic small, round to slightly irregular lymphocytes (Hematoxily-eosin, ×400). (B, C) Immunohistochemistry for CD79a and CD5 are strongly positive in atypical tumor cells (×100).
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