Journal List > Tuberc Respir Dis > v.71(5) > 1001676

Cho, Yoon, and Hyun: E6 Oncoprotein Expression in Non-Small Cell Lung Cancer Patients

Abstract

Background

Lung cancer is the leading cause of cancer deaths in the world. Human papillomavirus (HPV) infection and E6 oncoprotein expression are known risk factors for the development of non-small cell lung cancer (NSCLC). This study was performed to evaluate the prevalence of HPV 16/18 E6 oncoprotein expression in patients with NSCLC.

Methods

Immunohistochemical stains of the HPV 16/18 E6 oncoprotein were performed in tumor tissues from 68 patients with NSCLC who underwent curative surgery from March 2006 to November 2008.

Results

The E6 oncoprotein was expressed in 29.4%of patients with NSCLC and a statistical analysis revealed that E6 oncoprotein expression was significantly higher in females (p=0.028), never smokers (p=0.045), and patients with adenocarcinoma (p=0.022) than that in other patients.

Conclusion

The E6 oncoprotein was expressed in 29.4% of patients with NSCLC. Further studies detecting HPV infection and E6 oncoprotein expression in never smoking patients with NSCLC are needed.

Figures and Tables

Figure 1
Immunohistochemical staining for human papillomavirus (HPV) 16/18 E6 oncoprotein in lung tumors. The E6 oncoprotein was expressed in squamous cell carcinoma (A, ×400) and adenocarcinoma (B, ×400).
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Table 1
Relationship between human papillomavirus (HPV) 16/18 E6 oncoprotein expression and clinicopathological variables
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Values are presented as number (%).

SCC: squamous cell carcinoma; AD: adenocarcinoma.

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