Journal List > Tuberc Respir Dis > v.71(5) > 1001674

Park, Jung, Eun, Cheon, Seong, Park, Park, Park, Jung, Kim, Kim, and Lee: Respiratory Virus Detection Rate in Patients with Severe or Atypical Community-acquired Pneumonia

Abstract

Background

Community-acquired pneumonia (CAP) is an important cause of morbidity and mortality throughout the world in all age groups. Viral causes of CAP are less well characterized than bacterial causes. We analyzed the characteristics of hospitalized patients with CAP who had a viral pathogen detected by multiplex polymerase chain reaction (PCR).

Methods

Multiplex real-time PCR was performed for respiratory viruses in samples collected from 520 adults who developed CAP at Chungnam National University Hospital. Clinical, laboratory, and radiological features at presentation as well as other epidemiological data were analyzed.

Results

Of 520 patients with CAP, a viral pathogen was detected in 60 (11.5%), and influenza A was the most common. The virus detection rate in patients with CAP was highest in November. Two or more pathogens were detected in 13 (21.7%) patients. Seven patients had severe disease and were administered in the intensive care unit. Most patients (49/60, 81.7%) had comorbidities. However, nine (15%) patients had no comorbidities, and their age was <60 years. The ground glass opacity pattern was the most common radiological feature. Seven (11.7%) patients died from CAP.

Conclusion

Viral pathogens are commonly detected in patients with CAP, and a respiratory virus may be associated with the severity and outcome of pneumonia. Careful attention should be paid to the viral etiology in adult patients with CAP.

Figures and Tables

Figure 1
(A) Monthly distribution of the total number of patients with pneumonia who had a viral pathogen detected. Monthly distribution of the number of patients with pneumonia who had a influenza A virus (B) and parainfulenza virus and RSV (C) detected.
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Table 1
Baseline characteristics
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*Values in parenthesis represent ranges.

Table 2
Detected viruses
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A: detected number of each virus; B: cases in which two viruses were detected; C: cases in which three viruses were detected; D: cases in which four viruses were detected.

Table 3
Radiologic findings
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*p=0.26.

Table 4
Laboratory findings
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CRP: C reactive protein; LDH: lactate dehydrogenase; AST: aspartate aminotransferase; ALT: alanine aminotransferase.

References

1. MHW statistics DB. Ministry of Health and Welfare. c2011. cited 2011 Nov 5. Seoul: Ministry of Health and Welfare;Available from:http://stat.mw.go.kr[homepate on the internet]. Ministry of Health and Welfare Statistics DB; National Health Insurance part; [updated 2010 DEC 9; cited 2011 JAN 10]. Available from:http://stat.mw.go.kr/stat/data/cm_data_list.jsp? menu_code=MN01010202Accessed May 10, 2011.
2. Song JH, Jung KS, Kang MW, Kim DJ, Pai H, Suh GY, et al. Treatment guidelines for community-acquired pneumonia in Korea: an evidence-based approach to appropriate antimicrobial therapy. Tuberc Respir Dis. 2009. 67:281–302.
3. Crowe JE Jr. Human metapneumovirus as a major cause of human respiratory tract disease. Pediatr Infect Dis J. 2004. 23:11 Suppl. S215–S221.
4. van der Hoek L, Pyrc K, Berkhout B. Human coronavirus NL63, a new respiratory virus. FEMS Microbiol Rev. 2006. 30:760–773.
5. Hayden FG. Rhinovirus and the lower respiratory tract. Rev Med Virol. 2004. 14:17–31.
6. Lassaunière R, Kresfelder T, Venter M. A novel multiplex real-time RT-PCR assay with FRET hybridization probes for the detection and quantitation of 13 respiratory viruses. J Virol Methods. 2010. 165:254–260.
7. Brittain-Long R, Westin J, Olofsson S, Lindh M, Andersson LM. Prospective evaluation of a novel multiplex real-time PCR assay for detection of fifteen respiratory pathogens-duration of symptoms significantly affects detection rate. J Clin Virol. 2010. 47:263–267.
8. File TM. Community-acquired pneumonia. Lancet. 2003. 362:1991–2001.
9. Jennings LC, Anderson TP, Beynon KA, Chua A, Laing RT, Werno AM, et al. Incidence and characteristics of viral community-acquired pneumonia in adults. Thorax. 2008. 63:42–48.
10. Johnstone J, Majumdar SR, Fox JD, Marrie TJ. Viral infection in adults hospitalized with community-acquired pneumonia: prevalence, pathogens, and presentation. Chest. 2008. 134:1141–1148.
11. Marcos MA, Esperatti M, Torres A. Viral pneumonia. Curr Opin Infect Dis. 2009. 22:143–147.
12. Glezen P, Denny FW. Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973. 288:498–505.
13. Falsey AR, Walsh EE. Viral pneumonia in older adults. Clin Infect Dis. 2006. 42:518–524.
14. Abed Y, Boivin G. Treatment of respiratory virus infections. Antiviral Res. 2006. 70:1–16.
15. Jefferson T, Demicheli V, Rivetti D, Jones M, Di Pietrantonj C, Rivetti A. Antivirals for influenza in healthy adults: systematic review. Lancet. 2006. 367:303–313.
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