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Park, Park, Oh, Rhee, Lee, Park, Lim, and Korean Asthma Study Group: The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2011; 71(1): 24-29.

Published online: 31 July 2011

DOI: https://doi.org/10.4046/trd.2011.71.1.24

The Association of Obesity, Airway Hyperresponsiveness and Atopy in Chronic Cough Patients: Results of a Two-Center Study

So Yong Park, M.D.1, Jong Won Park, M.D.1, Yeon Mok Oh, M.D., Ph.D.2, Yang Keun Rhee, M.D., Ph.D.3, Young Mok Lee, M.D.4, Yong Bum Park, M.D.1, *, Seong Yong Lim, M.D., Ph.D.5, *; Korean Asthma Study Group

1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Hallym University College of Medicine, Seoul, Korea.

2Department of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.

4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Soonchunhyang University College of Medicine, Seoul, Korea.

5Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University College of Medicine, Seoul, Korea.

Address for correspondence: Yong Bum Park, M.D. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 445, Gil-dong, Gangdong-gu, Seoul 134-701, Korea. Phone: 82-2-2225-2754, Fax: 82-2-478-6925, bfspark@medimail.co.kr

Seong Yong Lim, M.D., Ph.D. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Pyeong-dong, Jongno-gu, Seoul 110-746, Korea. Phone: 82-2-2001-2491, Fax: 82-2-2001-1596, mdlimsy@skku.edu

Equal contributor:

*These two authors equally contributed to this article.

Received 28 April 2011       Accepted 24 June 2011

Copyright © 2011. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

The rising prevalence of asthma worldwide may be associated with the rising prevalence of obesity in developed nations. Although several studies have suggested a relationship between asthma and obesity, controversy still remains. The aim of this study was to examine the relationship between obesity and asthmatic factors such as atopy, eosinophilia, serum total Ig E and bronchial hyperresponsiveness in chronic cough patients.

Methods

This study was a retrospective, observational study in two centers done between January 2007 and June 2008. The subjects included individuals who had a chronic cough. We examined body mass index (BMI) to measure obesity and pulmonary function. We did a metacholine provocation test for airway hyperresponsiveness (AHR), a skin prick test for atopy, and tests for blood eosinophils and serum IgE.

Results

A total of 1022 subjects were included. Airway hyperresponsiveness was not related with obesity (p=0.06), and atopy incidence was significant higher in non obese patients (p=0.00). There was no significant difference in serum IgE and blood eosinophil counts between obese and non obese patients. Forced expiratory volue in one second (FEV1)/forced vital capacity (FVC) was significantly reduced in obese patients (p=0.03), but FEV1 and FVC were no significant difference between obese and non obese patients.

Conclusion

There is no relationship between obesity and bronchial hyperresponsiveness. The nonobese group appears to have more atopy. The relationship between obesity and bronchial hyperresponsiveness and atopy need further investigation.

Keywords: Obesity, Bronchial Hyperresponsiveness, Dermatitis, Atopic

Figures and Tables

Table 1
Clinical characteristics of study population
trd-71-24-i001

Data were calculated by t-test.

*Mean±2 SD.

BMI: body mass index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity; SD: standard deviation.

Table 2
Characteristics according to BMI
trd-71-24-i002

Values are presented number (%) unless otherwise indicated

Data were calculated by t-test.

*Mean±2 SD, †p<0.05.

BMI: body mass index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity.

Table 3
Difference of AHR according to BMI
trd-71-24-i003

Data were calculated by chi-squire test.

AHR: airway hyperresponsiveness; BMI: body mass index.

Table 4
Difference of atopy according to BMI
trd-71-24-i004

Data were calculated by chi-square test.

BMI: body mass index.

Table 5
Characteristics according to AHR
trd-71-24-i005

Data were calculated by t-test.

*Mean±2 SD, †p<0.05.

AHR: airway hyperresponsiveness; BMI: body mass index; FEV1: forced expiratory volume in one second; FVC: forced vital capacity.

Table 6
Difference of atopy according to AHR
trd-71-24-i006

Data were calculated by chi-squire test.

AHR: airway hyperresponsiveness; OR: odd ratio; CI: confidence interval.

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Young Mok Lee
https://orcid.org/http://orcid.org/0000-0003-4039-0456

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