Abstract
Background
The clinicopathologic characteristics of patients with non-small cell lung cancer (NSCLC) have been changing. Recently, Positron emission tomography-computed tomography (PET-CT) has usually been used for diagnosis, follow-up to treatment and surveillance of NSCLC. We studied the pattern of recurrence and prognosis in patients who underwent complete resection for NSCLC according to histologic subtype.
Methods
All patients who underwent complete resection for pathological stage I or II NSCLC between January 2005 and June 2009 were identified and clinical records were reviewed retrospectively, especially the histologic subtype.
Results
Recurrences were identified in 50 of 112 patients who had complete resection of an NSCLC. Sites of recurrence were locoregional in 15 (30%), locoregional and distant in 20 (40%), and distant in 15 (30%). Also, sites of recurrence were intra-thoracic in 29 (58%), extrathoracic and intra-thoracic recurrence in 15 (30%), and extrathoracic in 6 (12%). In locoregional recurrence, there was 37% recurrence for non-squamous cell carcinoma (non-SQC) and 25% for squamous cell carcinoma (SQC). In distant recurrence, there was 39% recurrence for non-SQC and 18% for SQC. Locoregional recurrence in the bronchial stump was more common in SQC than non-SQC (14% vs. 45%, p=0.025). Prognosis of recurrence was not influenced by histologic subtype and the recurrence-free survival curve showed that the non-SQC group did not differ from the SQC group according to stage.
Figures and Tables
Figure 1
Recurrence-free survival curve shows that risk of recurrence does not differ between non-squamous and squamous cell carcinoma in stage I. SQC: squamous cell carcinoma.
![trd-70-330-g001](/upload/SynapseData/ArticleImage/0003trd/trd-70-330-g001.jpg)
Figure 2
Recurrence-free survival curve shows that risk of recurrence does not differ between non-squamous and squamous cell carcinoma in stage II. SQC: squamous cell carcinoma.
![trd-70-330-g002](/upload/SynapseData/ArticleImage/0003trd/trd-70-330-g002.jpg)
Table 4
Comparison of site of intrathoracic recurrence between non-squamous and squamous cell carcinoma
![trd-70-330-i004](/upload/SynapseData/ArticleImage/0003trd/trd-70-330-i004.jpg)
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