Association of Body Composition with the Development of Airway Hyper-Responsiveness

Hyun Jung Jin; Kyeong-Cheol Shin; Jin Hong Chung; Kwan Ho Lee

doi:10.4046/trd.2011.70.3.235

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Jin, Shin, Chung, and Lee: Association of Body Composition with the Development of Airway Hyper-Responsiveness

Original Article

Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2011; 70(3): 235-241.

Published online: 31 March 2011

DOI: https://doi.org/10.4046/trd.2011.70.3.235

Association of Body Composition with the Development of Airway Hyper-Responsiveness

Hyun Jung Jin, M.D., Kyeong-Cheol Shin, Ph.D., Jin Hong Chung, Ph.D., Kwan Ho Lee, Ph.D.

Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Address for correspondence: Kwan Ho Lee, Ph.D. Department of Internal Medicine, Yeungnam University, 371-1, Daemyeong 5-dong, Nam-gu, Daegu 705-717, Korea. Phone: 82-53-620-3838, Fax: 82-53-623-8201, ghlee@med.yu.ac.kr

Received 27 January 2011 Accepted 4 March 2011

Abstract

Background

The rising prevalence of asthma may be associated with the rising prevalence of obesity in developed nations. There are several studies showing that obesity increases the risk of asthma in adults. We investigated the association of each body composition scale and bronchial hyper-responsiveness.

Methods

This study involved a retrospective review of the existing records for 279 subjects with respiratory symptoms, who underwent a pulmonary function test, a methacholine challenge test and a body composition test between May 2007 and June 2009.

Results

Of the 279 subjects, 179 (64%) were female. There was a statistically significant difference in fat free mass and in fat free mass index between the normal bronchial responsiveness group and bronchial hyper-responsiveness group (p=0.036; p=0.000). There was no significant differences in body mass index, in fat mass and fat free mass index in the normal bronchial responsiveness group and bronchial hyper-responsiveness group in males. However in females, body mass index and fat free mass index were increased in the bronchial hyper-responsiveness group (p=0.044; p=0.000). Total body water (kg), fat free mass (kg) and soft lean mass (kg) were significantly different between the normal bronchial responsiveness group and bronchial hyper-responsiveness group (p=0.002; p=0.000; p=0.000).

Conclusion

This study showed significant differences in fat free mass and in fat free mass index between the normal bronchial responsiveness group and the bronchial hyper-responsiveness group. In females, BMI, soft lean mass, and total body water showed significant differences between the normal bronchial responsiveness group and the bronchial hyper-responsiveness group. We concluded that bronchial hyper-responsiveness was associated with not only body mass index but also fat free mass index in female bronchial asthma.

Keywords: Asthma, Body Composition, Body Mass Index

Figures and Tables

Table 1

Subject characteristics

Data are presented as means±SD for continuous variables or proportions for categorical variables.

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness; SD: standard deviation.

Table 2

Difference of body composition by BHR in total subjects

Data are presented as means±SD for continuous variables.

^*p<0.05.

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness; SD: standard deviation.

Table 3

Difference of body composition by BHR in male

Data are presented as means±SD for continuous.

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness; SD: standard deviation.

Table 4

Difference of body composition by BHR in female

Data are presented as means±SD for continuous variables.

^*p<0.05.

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness; SD: standard deviation.

Table 5

Incidence of Bronchial hyper-responsiveness in relation to body composition in male

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness.

Table 6

Incidence of bronchial hyper-responsiveness in relation to body composition in female

^*p<0.05.

BMI: body mass index; FFMI: fat free mass index; BHR: bronchial hyper-responsiveness.

Notes

This research was supported by the Yeungnam University research grants in 2008.

References

1. Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA. 2003. 289:76–79.

2. Bergström A, Pisani P, Tenet V, Wolk A, Adami HO. Overweight as an avoidable cause of cancer in Europe. Int J Cancer. 2001. 91:421–430.

3. Bianchini F, Kaaks R, Vainio H. Overweight, obesity, and cancer risk. Lancet Oncol. 2002. 3:565–574.

4. Bergström A, Hsieh CC, Lindblad P, Lu CM, Cook NR, Wolk A. Obesity and renal cell cancer--a quantitative review. Br J Cancer. 2001. 85:984–990.

5. Chang KJ, Koo HS, Lee HS, Jo YA. Association between asthma and obesity in national health and nutrition survey. Korean J Asthma Allergy Clin Immunol. 2005. 25:262–268.

6. Korea Center for Disease Control and Prevention. National health & nutrition examination survey (KNHANES 4), Nutrition survey. 2007. Seoul: Ministry for Health, Welfare and Family Affairs.

7. Crater SE, Platts-Mills TA. Searching for the cause of the increase in asthma. Curr Opin Pediatr. 1998. 10:594–599.

8. van Veen IH, Ten Brinke A, Sterk PJ, Rabe KF, Bel EH. Airway inflammation in obese and nonobese patients with difficult-to-treat asthma. Allergy. 2008. 63:570–574.

9. Mishra V. Effect of obesity on asthma among adult Indian women. Int J Obes Relat Metab Disord. 2004. 28:1048–1058.

10. Lorentzen MS, Vestbo J, Lange P. Are obesity and overweight risk factors of asthma? Ugeskr Laeger. 2001. 163:4999–5003.

11. Akerman MJ, Calacanis CM, Madsen MK. Relationship between asthma severity and obesity. J Asthma. 2004. 41:521–526.

12. Mosen DM, Schatz M, Magid DJ, Camargo CA Jr. The relationship between obesity and asthma severity and control in adults. J Allergy Clin Immunol. 2008. 122:507–511.

13. Pelegrino NR, Faganello MM, Sanchez FF, Padovani CR, Godoy I. Relationship between body mass index and asthma severity in adults. J Bras Pneumol. 2007. 33:641–646.

14. Taylor B, Mannino D, Brown C, Crocker D, Twum-Baah N, Holguin F. Body mass index and asthma severity in the National Asthma Survey. Thorax. 2008. 63:14–20.

15. Varraso R, Siroux V, Maccario J, Pin I, Kauffmann F. Epidemiological Study on the Genetics and Environment of Asthma. Asthma severity is associated with body mass index and early menarche in women. Am J Respir Crit Care Med. 2005. 171:334–339.

16. Chen Y, Dales R, Jiang Y. The association between obesity and asthma is stronger in nonallergic than allergic adults. Chest. 2006. 130:890–895.

17. Celedón JC, Palmer LJ, Litonjua AA, Weiss ST, Wang B, Fang Z, et al. Body mass index and asthma in adults in families of subjects with asthma in Anqing, China. Am J Respir Crit Care Med. 2001. 164:1835–1840.

18. Jaffrin MY. Body composition determination by bioimpedance: an update. Curr Opin Clin Nutr Metab Care. 2009. 12:482–486.

19. Nakadomo F, Tanaka K, Hazama T, Maeda K. Assessment of body composition by bioelectrical impedance analysis: effects of skin resistance on impedance. Ann Physiol Anthropol. 1990. 9:109–114.

20. Lukaski HC, Bolonchuk WW, Hall CB, Siders WA. Validation of tetrapolar bioelectrical impedance method to assess human body composition. J Appl Physiol. 1986. 60:1327–1332.

21. Houtkooper LB, Lohman TG, Going SB, Hall MC. Validity of bioelectric impedance for body composition assessment in children. J Appl Physiol. 1989. 66:814–821.

22. Kim HS, Park HS. Reliability and validity of bioimpedance body composition analyzer. J Korean Orient Assoc Stud Obes. 2002. 11:389–397.

23. Chatham M, Bleecker ER, Norman P, Smith PL, Mason P. A screening test for airways reactivity. An abbreviated methacholine inhalation challenge. Chest. 1982. 82:15–18.

24. Chen Y, Dales R, Krewski D, Breithaupt K. Increased effects of smoking and obesity on asthma among female Canadians: the National Population Health Survey, 1994-1995. Am J Epidemiol. 1999. 150:255–262.

25. Shaheen SO, Sterne JA, Montgomery SM, Azima H. Birth weight, body mass index and asthma in young adults. Thorax. 1999. 54:396–402.

26. Luder E, Melnik TA, DiMaio M. Association of being overweight with greater asthma symptoms in inner city black and Hispanic children. J Pediatr. 1998. 132:699–703.

27. Camargo CA Jr, Weiss ST, Zhang S, Willett WC, Speizer FE. Prospective study of body mass index, weight change, and risk of adult-onset asthma in women. Arch Intern Med. 1999. 159:2582–2588.

28. Hernández García IA, Gutiérrez Gutiérrez AM, Gallardo Lozano E. Effect of weight reduction on the clinical and hormonal condition of obese anovulatory women. Ginecol Obstet Mex. 1999. 67:433–437.

29. McLachlan CR, Poulton R, Car G, Cowan J, Filsell S, Greene JM, et al. Adiposity, asthma, and airway inflammation. J Allergy Clin Immunol. 2007. 119:634–639.

30. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest. 2003. 112:1796–1808.

31. Sood A, Ford ES, Camargo CA Jr. Association between leptin and asthma in adults. Thorax. 2006. 61:300–305.

32. Shore SA, Schwartzman IN, Mellema MS, Flynt L, Imrich A, Johnston RA. Effect of leptin on allergic airway responses in mice. J Allergy Clin Immunol. 2005. 115:103–109.

33. Sood A, Cui X, Qualls C, Beckett WS, Gross MD, Steffes MW, et al. Association between asthma and serum adiponectin concentration in women. Thorax. 2008. 63:877–882.

34. Shore SA, Terry RD, Flynt L, Xu A, Hug C. Adiponectin attenuates allergen-induced airway inflammation and hyperresponsiveness in mice. J Allergy Clin Immunol. 2006. 118:389–395.

35. Jang AS, Kim TH, Park JS, Kim KU, Uh ST, Seo KH, et al. Association of serum leptin and adiponectin with obesity in asthmatics. J Asthma. 2009. 46:59–63.

36. Jartti T, Saarikoski L, Jartti L, Lisinen I, Jula A, Huupponen R, et al. Obesity, adipokines and asthma. Allergy. 2009. 64:770–777.

37. Jang AS, Park JS, Park SW, Kim DJ, Uh ST, Seo KH, et al. Obesity in aspirin-tolerant and aspirin-intolerant asthmatics. Respirology. 2008. 13:1034–1038.

38. Naimark A, Cherniack RM. Compliance of the respiratory system and its components in health and obesity. J Appl Physiol. 1960. 15:377–382.

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