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Lee, Sim, Yoon, Kim, Park, Kho, Byun, Choi, and Kim: A Case of Cranial Nerve Palsy as a Paraneoplastic Syndrome in Non-Small Cell Lung Cancer
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2011; 70(2): 160-164.

Published online: 28 February 2011

DOI: https://doi.org/10.4046/trd.2011.70.2.160

A Case of Cranial Nerve Palsy as a Paraneoplastic Syndrome in Non-Small Cell Lung Cancer

Young Mi Lee, M.D.1, Woo Ho Sim, M.D.1, Sun Och Yoon, M.D.2, Song Yee Kim, M.D.1, Jung Soo Park, M.D.1, Bo Gun Kho, M.D.1, Min Kwang Byun, M.D.1, Young Chul Choi, M.D.3, Hyung Jung Kim, M.D.1

1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

3Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.

Address for correspondence: Hyung Jung Kim, M.D. Department of Internal Medicine, Gangnam Severance Hospital, 712, Eonju-ro, Gangnam-gu, Seoul 135-270, Korea. Phone: 82-2-2019-3316, Fax: 82-2-3463-3882, khj57@yuhs.ac

Received 12 August 2010       Accepted 18 October 2010

Copyright © 2011. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Paraneoplastic neurologic syndrome is a group of assorted disorders resulting from damage to the nervous system in cancer, remote from primary site, and not related to metastasis, infection, or metabolic disorder associated with cancer. Patient with small cell lung cancer sometimes shows various neurological syndromes, but patient with non-small cell lung cancer rarely shows neurologic syndromes and few antineuronal antibodies have been found. Here, we report a case of 53-year-old male patient who developed ptosis and extraocular muscular limitation of left eye due to third and forth cranial nerve palsy in non-small cell lung cancer without brain metastasis. These neurologic symptoms improved after lobectomy without any other treatment immunotherapy.

Keywords: Paraneoplastic Syndromes, Nervous System, Carcinoma, Non-Small-Cell Lung, Paralysis, Cranial Nerves

Figures and Tables

Figure 1
Ptosis of left eye improve after removal of lung cancer in eye opening (before [A] and after [E]) and EOM limitation of vertical and medial gaze (B~D are before, and F~H are after of frontal gaze, up gaze and right up gaze).
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Figure 2
(A) CT Chest computed tomography shows cavitary mass in upper lobe ofright lung. (B) PET - CT shows no distant metastasis.
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Figure 3
Microscopic finding shows an adenocarcinoma mixed acinar and soli (H&E stain, ×100).
trd-70-160-g003

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