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Yang, Ryu, Ko, Park, Park, Park, Park, Bak, Ko, and Park: A Case of Pulmonary Sarcoidosis with Elevated Carcinoembryonic Antigen (CEA)
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2010; 69(1): 48-51.

Published online: 31 July 2010

DOI: https://doi.org/10.4046/trd.2010.69.1.48

A Case of Pulmonary Sarcoidosis with Elevated Carcinoembryonic Antigen (CEA)

Mi Yean Yang, M.D.1, Yang Seon Ryu, M.D.1, Hee Ja Ko, M.D.1, Se Kyng Park, M.D.1, Jong Sook Park, M.D., Ph.D.1, Chun Sik Park, M.D., Ph.D.1, Jae Sung Park, M.D., Ph.D.2, Sang Hyen Bak, M.D., Ph.D.2, Eun Suk Ko, M.D., Ph.D.3, Jeong Mi Park, M.D., Ph.D.4

1Division of Pulmonology & Allergy, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

2Department of Radiology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

3Department of Pathology, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

4Department of Nuclear Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea.

Address for correspondence: Chun Sik Park, M.D., Ph.D. Division of Pulmonology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, 1174, Jung-dong, Wonmi-gu, Bucheon 420-853, Korea. Phone: 82-32-621-5024, Fax: 82-32-621-5016, schalr@schbc.ac.kr

Received 1 February 2010       Accepted 24 May 2010

Copyright © 2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Sarcoidosis is a multi-systemic granulomatous disorder of unknown etiology. The characteristic pathological finding is the presence of non-caseating granulomas. The lungs are primarily affected, however other organs may be involved causing various symptoms and ambiguous laboratory findings can be present. There are a few reported cases of sarcoidosis with elevated tumor markers. We describe a 68-year-old woman presenting with sarcoidosis showing elevated serum carcinoembryonic antigen (CEA). The possibility of cancer arising from serum CEA such as gastrointestinal cancer, breast cancer and lung cancer was excluded. A transbronchial lung biopsy demonstrated a non-caseating granuloma without necrosis. As a result prescribed 30 mg prednisolone daily to the patient and serum CEA was decreased after 1 month of treatment. We report a case of pulmonary sarcoidosis with elevated serum CEA.

Keywords: Sarcoidosis, Pulmonary, Tumor Markers, Biological, Carcinoembryonic Antigen

Figures and Tables

Figure 1
Chest radiograph shows a bilateral hilar enlargement and no parenchymal lesions.
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Figure 2
Chest CT scan with enhancement shows enlarged lymph nodes at both hilum, both paratracheal, left paraaotic, AP window and subcarinal nodal station.
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Figure 3
PET-CT scan reveals multiple increased FDG uptake in bilateral mediastinal, hilar, and portocaval nodal station (maximum SUV: 5.06).
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Figure 4
Transbronchial lung biopsy shows a discrete non-caseating granuloma (H&E stain, ×100).
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Table 1
Cases of sarcoidosis with elevated tumor markers
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*Total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic washings, peritoneal biopsies, and partial omentectomy.

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