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Kim, Bae, Choi, Hwang, Shin, Kim, Lee, Kim, Jeon, Park, Kim, Lee, and Park: Depressive Conditions in Relation to Asthma Severity and Control
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2010; 69(4): 265-270.

Published online: 31 October 2010

DOI: https://doi.org/10.4046/trd.2010.69.4.265

Depressive Conditions in Relation to Asthma Severity and Control

Won Jin Kim, M.D.1, Hyunsook Bae, M.D.2, Bo Kyung Choi, M.D.1, Jong Min Hwang, M.D.1, Kyung Hwa Shin, M.D.1, Mi Hyun Kim, M.D.1, Kwangha Lee, M.D.1, Ki Uk Kim, M.D.1, Doo Soo Jeon, M.D.1, Hye-Kyung Park, M.D.1, Yun Seong Kim, M.D.1, Min Ki Lee, M.D.1, Soon Kew Park, M.D.1

1Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.

2Department of Preventive and Occupational Medicine, Pusan National University School of Medicine, Busan, Korea.

Address for correspondence: Soon Kew Park, M.D. Department of Internal Medicine, Pusan National University School of Medicine, 1-10, Ami-dong, Seo-gu, Busan 602-739, Korea. Phone: 82-51-240-7222, Fax: 82-51-254-3127, snkpark@pusan.ac.kr

Received 7 July 2010       Accepted 9 August 2010

Copyright © 2010. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

Psychological factors are increasingly recognized for their influence on the course of asthma, on a worldwide basis. The aim of this study was to assess the presence of depression, anxiety, and asthma-related quality of life in patients with asthma and to evaluate their impact on severity and control of asthma.

Methods

We assessed the severity of asthma by comparing patients' current medications to GINA guideline. The patients were classified into the controlled group (asthma patients with controlled disease) or into the uncontrolled group (asthma patients with uncontrolled disease), which included partly controlled and uncontrolled patients, again based on GINA guideline 2004. Patient-reported depressive symptoms, anxiety, and asthma-related quality of life were evaluated using the Beck Depression Inventory (BDI), the State-Trait Anxiety Inventory (STAI), and Korean asthma quality of life (KAQLQ).

Results

One hundred and twenty patients were enrolled (mean age, 55±1 years; 65% women). Among the 120 patients, 14 (12%) patients were classified as having mild asthma, 88 (73%) as having moderate asthma, and 18 (15%) as having severe asthma. Eighty-one (67%) of the 120 patients were controlled. The asthma-related quality of life showed the difference according to severity of asthma (p=0.002). The prevalence of depression was lower (10% vs 26%, p=0.024) and the asthma-related quality of life was higher (59.951 (29~75) vs 35.103 (18~72), p≤0.001) in the controlled group. Higher trait anxiety score and lower asthma-related quality of life were associated with depression (p<0.001, p=0.002, respectively).

Conclusion

Psychological factors, such as anxiety and depression, are strongly associated with asthma control. Therefore, screening and management of depression is needed in patients with asthma.

Keywords: Asthma, Depression, Anxiety

Figures and Tables

Table 1
Dermographic and clinical characteristics of subjects
trd-69-265-i001

Values are expressed as means±SD or frequencies (%).

Table 2
Psychological status of depression, anxiety and QOL according to asthma severity
trd-69-265-i002

Values are expressed as medians (ranges) or frequencies (%).

QOL: quality of life; BDI: Beck Depression Inventory; KAQLQ: Korean asthma-related quality of life.

*ANOVA, †Cochran-Armitage trend test, ‡Kruskal-Wallis test.

Table 3
Psychological status of depression, anxiety and QOL according to asthma control
trd-69-265-i003

Values are expressed as medians (ranges) or frequencies (%).

QOL: quality of life; BDI: Beck Depression Inventory; KAQLQ: Korean asthma-related quality of life.

Table 4
Clinical characteristics of patients with asthma with or without depression by BDI scoring
trd-69-265-i004

Values are expressed as means±SD, medians (ranges) or frequencies (%).

BDI: Beck Depression Inventory; KAQLQ: Korean asthma-related quality of life.

Acknowledgements

This work was supported for two years by Pusan National University research grant.

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