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Oh, Lee, Hong, Jung, Choi, Kim, Ahn, and Chang: A Case of Malignant Rhabdoid Tumor in the Anterior Mediastinum
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2009; 67(5): 462-466.

Published online: 30 November 2009

DOI: https://doi.org/10.4046/trd.2009.67.5.462

A Case of Malignant Rhabdoid Tumor in the Anterior Mediastinum

Kyung Jin Oh, M.D.1, Ki Byung Lee, M.D.1, Soon Won Hong, M.D., Ph.D.2, Kyo Tae Jung, M.D.1, Hong Kyu Choi, M.D.1, Hyung Jung Kim, M.D., Ph.D.1, Chul Min Ahn, M.D., Ph.D.1, Yoon Soo Chang, M.D., Ph.D.1

1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.

Address for correspondence: Yoon Soo Chang, M.D., Ph.D. Department of Internal Medicine, Yonsei University College of Medicine, 712, Eonju-ro, Gangnam-gu, Seoul 135-720, Korea. Phone: 82-2-2019-3309, Fax: 82-2-3463-3882, yschang@yuhs.ac

Received 1 September 2009       Accepted 28 September 2009

Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Malignant rhabdoid tumors arise primarily from the kidney. Extrarenal malignant rhabdoid tumors are rare, with the liver, central nervous system, and skin reported as the primary sites. Malignant rhabdoid tumors of the mediastinum are extremely rare among extrarenal malignant rhadoid tumors; only 3 cases have been reported to date, all characterized by aggressive clinical behavior. We experienced a 35-year-old woman diagnosed with malignant rhabdoid tumor in the anterior mediastinum with multiple metastases. The tumor was surgically unresectable, and treated with palliative radiation therapy. Three-month after radiation treatment, she died from dissemination of the malignant rabdoid tumor.

Keywords: Rhabdoid Tumor, Mediastinum

Figures and Tables

Figure 1
Chest X-ray suggests huge mass lesion on left upper lung fileds (A, B).
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Figure 2
Chest computed tomography shows 8.5 cm sized anterior mediastinal mass with contrast window (A), with lung window (B).
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Figure 3
Whole body bone scan suggests metastasis to left lower posterior ribs (A), and PET-CT shows multiple metastasis to lymph node, both adrenal glands (B).
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Figure 4
Histopathologic findings shows round tumor cells infiltrating surrounding tissues with eosinophilic cytoplasm containing amorphous inclusion body (H&E stain; A, ×40, B, ×400), positive staining in cytoplasm (Immunohistochemical staining; C, cytokeratin, ×400, D, vimentin, ×400).
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