Journal List > Tuberc Respir Dis > v.67(4) > 1001437

Chi, Ryu, Lim, Shin, Ban, Oh, Kwon, Kim, Lim, Kim, Choi, Song, and Seon: A Case of Bronchiolitis Interstitial Pneumonitis

Abstract

Bronchiolitis interstitial pneumonitis (BIP), an unclassified and newly described interstitial pneumonia, has a combined feature of prominent bronchiolitis, interstitial inflammation, and fibrosis. It is distinct from bronchiolitis obliterans or bronchiolitis obliterans organizing pneumonia (BOOP). BIP has a better prognosis than common cases of interstitial pneumonia. However, BIP has a poorer prognosis than BOOP. BIP's response to corticosteroids is not as successful as BOOP's response to this treatment. We encountered the case of a 31-year-old woman with BIP with an initial presentation of dyspnea and a cough that had lasted for 3 months. The patient's chest CT scan demonstrated patchy ground glass opacities and multiple ill-defined centrilobular nodules in both lungs, suggesting military tuberculosis or nontuberculous mycobacterial infection. A video-assisted thoracoscopic lung biopsy resulted in the diagnosis of BIP. Clinical symptoms, pulmonary lesions, and pulmonary function tests were improved after oral glucocorticoid therapy.

Figures and Tables

Figure 1
Radiologic findings of a patient with bronchiolitis interstitial pneumonitis before and after glucocorticoid therapy. (A) Initial chest radiography shows diffuse fine reticulonodular opacities and mixed multiple patchy opacities with peripheral predominance in both lungs. There is also fibrocalcified lesion in left upper lung field which is suggestive of inactive pulmonary TB lesion. (B) Follow-up chest radiography after completion of glucocorticoid therapy shows a marked resolution of diffuse fine reticulonodular opacities and mixed patchy opacities in both lungs. (C) An initial chest HRCT image (lung window setting) at the level of lower hemithorax shows bilateral symmetric multiple patchy areas of peribronchial ground-glass opacities (GGOs), diffuse bronchial and bronchiolar wall thickening, and mixed ill-defined centrilobular nodules in both lungs. (D) A follow-up chest HRCT image (lung window setting) at the same level of image of (C) after completion of glucocorticoid theraphy shows marked improvement of multiple patchy areas of peribronchial GGOs, diffuse bronchial and bronchiolar wall thickening, and mixed ill-defined centrilobular nodules in both lungs.
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Figure 2
The pathologic findings of lung specimen resected by video-assisted thoracoscopic surgery. (A) Resected lung specimen shows an architectural alteration of pulmonary alveolar structures and diffuse interstitial thickening (H&E stain, ×40). (B) The bronchiole shows a dilatation of bronchiole, mucostasis, and smooth muscle hyperplasia (H&E stain, ×100). (C) In peribronchiolar portion, mild interstitial thickening and fibrosis are predominantly shown (H&E stain, ×100).
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