Journal List > Tuberc Respir Dis > v.67(1) > 1001429

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Kim, Oh, Yu, Kim, Noh, Roh, Jung, Yoo, and Shim: A Case of Disseminated Mycobacterium intracellulare Infection in an Immunocompromised Host
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2009; 67(1): 32-36.

Published online: 31 July 2009

DOI: https://doi.org/10.4046/trd.2009.67.1.32

A Case of Disseminated Mycobacterium intracellulare Infection in an Immunocompromised Host

Sun Young Kim, M.D., Dong Wook Oh, M.D., Ji Hee Yu, M.D., Donghoi Kim, M.D., Sehui Noh, M.D., JaeHyung Roh, M.D., Sang-Su Jung, M.D., Dong-Jun Yoo, M.D., Tae Sun Shim, M.D.

Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Address for correspondence: Tae Sun Shim, M.D. Division of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. Phone: 82-2-3010-3892, Fax: 82-2-3010-6968, shimts@amc.seoul.kr

Received 28 May 2009       Accepted 22 June 2009

Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

We report a case of disseminated Mycobacterium intracellulare infection in a 31-year-old man who had been diagnosed as having dermatomyositis and systemic lupus erythematosus 3-years prior. The patient developed a left pleural effusion M. intracellulare was repeatedly isolated from the pleural fluid. After antimycobacterial treatment, the patient's pleural effusion resolved, but a left knee joint effusion developed newly and M. intracellulare was cultured from the joint fluid. At present, the patient has been taking antimycobacterial medication for 15 months but his left knee joint fluid remains positive for M. intracellulare. To our knowledge, this is the second reported case of disseminated NTM infection in a non-HIV infected patient in Korea.

Keywords: Mycobacterium avium complex, Disseminated infection, Immunocompromised host, Pleural effusion, Arthritis

Figures and Tables

Figure 1
(A) Chest X-ray shows left pleural effusion on admission and (B) decreased left pleural effusion after 8 months.
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Figure 2
Sagittal T1-weighted enhanced fat-suppressed magnetic resonance image shows synovial thickening with well enhancement and effusion (arrow) in left knee joint; and poorly defined bone marrow signal change in medial femoral condyle and tibial plateau. These findings are consistent with septic arthritis with osteomyelitis.
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