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Kang, Noh, Jang, Cho, Rhim, Noh, Kim, Kim, and Lee: A Case of Henoch-Schönlein Purpura Developed during Treatment of Lung Cancer
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2009; 67(3): 234-238.

Published online: 30 September 2009

DOI: https://doi.org/10.4046/trd.2009.67.3.234

A Case of Henoch-Schönlein Purpura Developed during Treatment of Lung Cancer

Min Soo Kang, M.D.1, Geum Yeub Noh, M.D.1, Young Joo Jang, M.D.1, Soo Youn Cho, M.D.2, Kyung Jin Rhim, M.D.3, Hee Sun Noh, M.D.1, Hye-Ryoun Kim, M.D.1, Cheol Hyeon Kim, M.D.1, Jae Cheol Lee, M.D.1

1Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.

2Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.

3Department of Dermatology, Korea Cancer Center Hospital, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.

Address for correspondence: Jae Cheol Lee, M.D. Department of Internal Medicine, Korea Cancer Center Hospital, 215-4, Gongneung-dong, Nowon-gu, Seoul 139-706, Korea. Phone: 82-2-970-1206, Fax: 82-2-970-2438, jclee@kcch.re.kr

Received 4 August 2009       Accepted 19 August 2009

Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Henoch-Schönlein Purpura (HSP) is a systemic vasculitis involving small vessels with the deposition of immune complexes containing IgA and C3, which is characterized by associated skin, joint, renal, and gastrointestinal manifestations. Although there were several causes such as autoimmunity, infection, and drugs, it also can be presented as a form of vasculitidies associated with malignancies. We report a case of HSP developed during treatment for non-small cell lung cancer in a 66-year-old man. Multiple purpuric skin lesions occurred in both legs after the first cycle of chemotherapy, which was diagnosed as HSP by clinical and pathologic examinations. Due to the itching sensation, topical steroid was applied and the patient was improved 3 weeks later without a scheduled change in chemotherapy.

Keywords: Lung neoplasms, Henoch-Schönlein purpura, Vasculitis

Figures and Tables

Figure 1
CT scan of the chest at the diagnosis of Lung cancer shows that 2.5 cm sized lung mass is located in LUL (arrow) with paratracheal, subcarinal and AP window lymphadenopathy (arrowhead).
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Figure 2
(A) Multiple purpuric skin lesions are presented on both lower legs at the diagnosis of Henoch-Schönlein purpura. (B) Previous purpuric skin lesions are mostly disappeared after the application of topical steroid.
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Figure 3
Chest PA taken at the diagnosis of Henoch-Schönlein purpura shows an unchanged lung nodule (arrow) in LUL field.
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Figure 4
(A) Microscopic finding presents the leukocytoclastic vasculitis with infiltrative neutrophils and lymphocytes in the superficial dermis (H&E stain, ×100). (B) Neutrophils and lymphocytes infiltrate into vascular wall with swollen endothelium under high microscopic field (H&E stain, ×400).
trd-67-234-g004

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