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Kim, Kim, Han, Kwan, Oh, Lim, and Kim: A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2009; 67(2): 145-147.

Published online: 31 August 2009

DOI: https://doi.org/10.4046/trd.2009.67.2.145

A Case of Anaphylaxis after the Treatment with Etoposide in a Patient with Small Cell Lung Cancer

Young-Il Kim, M.D.1, Kyu-Sik Kim, M.D.1, Eui-Ryoung Han, M.D.2, Yong-Soo Kwan, M.D.1, In-Jae Oh, M.D.1, Sung-Chul Lim, M.D.1, Young-Chul Kim, M.D.1

1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Chonnam National University Medical School, Gwangju, Korea.

2Department of Internal Medicine, Division of Allergy, Asthma and Clinical Immunology, Chonnam National University Medical School, Gwangju, Korea.

Address for correspondence: Kyu-Sik Kim, M.D. Lung and Esophageal Cancer Clinic, Chonnam National University Hwasun Hospital, 160, Ilsim-ri, Hwasun-eup, Hwasun-gun, Jeonnam 519-809, Korea. Phone: 82-61-379-7615, Fax: 82-61-379-7628, cyberkks@chonnam.ac.kr

Received 23 June 2009       Accepted 11 August 2009

Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Etoposide is a semi-synthetic derivative of podophyllotoxin that is effective against many cancers including small cell lung cancer. We report a case of etoposide-induced anaphylaxis in a 51-year-old woman who tolerated etoposide during her first cycle chemotherapy regimen. During the second cycle, she complained of generalized urticaria and dyspnea 5 minutes after being infused with etoposide. She recovered completely with antihistamine, corticosteroid and fluid replacement. The intradermal skin test with etoposide showed a clear positive immediate reaction. This case suggests that etoposide can induce IgE-mediated anaphylaxis.

Keywords: Etoposide, Anaphylaxis, Small cell lung carcinoma, Skin tests

Figures and Tables

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Figure 1
Intradermal skin tests with etoposide, cisplatin on the back of our case showed positive reactions at the concentrations of 1:100 and 1:10 of etoposide. The results of intradermal skin tests with cisplatin were all negative.

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