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Kim, Kim, Park, Choi, Lee, Hwang, Shin, Park, Park, Lee, Jang, Kim, Mo, Lee, Hyun, and Jung: Incidence of Immunoglobulin G Subclass Deficiencies in Patients with Bronchiectasis and the Clinical Characteristics of Patients with Immunoglobulin G Subclass Deficiency and Bronchiectasis
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2009; 66(4): 295-299.

Published online: 30 April 2009

DOI: https://doi.org/10.4046/trd.2009.66.4.295

Incidence of Immunoglobulin G Subclass Deficiencies in Patients with Bronchiectasis and the Clinical Characteristics of Patients with Immunoglobulin G Subclass Deficiency and Bronchiectasis

Chang Hwan Kim, M.D.1, Dong-Gyu Kim, M.D.2, Sung Hoon Park, M.D.2, Jeong-Hee Choi, M.D.2, Chang Youl Lee, M.D.2, Yong Il Hwang, M.D.2, Tae Rim Shin, M.D.2, Sang Myeon Park, M.D.2, Yong Bum Park, M.D.2, Jae Young Lee, M.D.2, Seung Hun Jang, M.D.2, Cheol-Hong Kim, M.D.2, Eun Kyung Mo, M.D.2, Myung Goo Lee, M.D.2, In-Gyu Hyun, M.D.2, Ki-Suck Jung, M.D.2

1Department of Internal Medicine and Sejong Medical Research Institute, Sejong General Hospital, Bucheon, Korea.

2Department of Internal Medicine, Hallym University College of Medicine, Chuncheon, Korea.

Address for correspondence: Dong-Gyu Kim, M.D. Division of Pulmonary, Allergy & Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, 896, Pyeongchon-dong, Dongan-gu, Anyang 431-070, Korea. Phone: 82-31-380-3715, Fax: 82-31-380-3973, dongyu@hallym.ac.kr

Received 7 March 2009       Accepted 15 April 2009

Copyright©2009. The Korean Academy of Tuberculosis and Respiratory Diseases. All rights reserved.

Abstract

Background

There are various etiologies causing bronchiectasis, but the cases without definite causes account for a quite high proportion. It is also uncertain that immunoglobulin G subclass deficiency (IgGSD) is associated with bronchiectasis. Therefore, we tried to measure the frequency of IgGSD in patients with bronchiectasis of unclear etiology, and to observe the clinical features of those patients with bronchiectasis and IgGSD.

Methods

For the outpatients of a university hospital who were diagnosed as bronchiectasis by chest CT, we produced comprehensive history taking and physical examinations, and finally selected 31 patients with bronchiectasis of unclear etiology.

Results

Two patients had total immunoglobulin G deficiency. The frequency of IgGSD was comparatively high (n=14). When we compared IgGSD group to normal immunoglobulin G subclass group, there were no significant differences in sex, age, and the frequency of sinusitis, bronchial asthma, and the abnormal lung function.

Conclusion

In cases of bronchiectasis without definite causes, it can be considered to measure the level of immunoglobulin G subclass. It is also probably worthwhile to further evaluate the relationship between IgGSD and bronchiectasis.

Keywords: Bronchiectasis, Etiology, Immunoglobulins

Figures and Tables

Table 1
The characteristics of patients with bronchiectasis of unclear etiology
trd-66-295-i001
Table 2
Comparison of the patients' characteristics between IgG3 deficiency group and normal IgG group
trd-66-295-i002

Two patients with total IgG deficiency were excluded.

*Pearson chi-square test, †Independent sample t-test.

Table 3
Comparison of the immunoglobulin levels between IgG3 deficiency group and normal IgG group
trd-66-295-i003

Two patients with total IgG deficiency were excluded.

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