Journal List > Tuberc Respir Dis > v.66(1) > 1001358

Moon, Han, Lee, Jeon, Lee, Cho, and Na: Clinical Characteristics and Prognosis of Lung Cancer Patients Admitted to the Medical Intensive Care Unit at a University Hospital

Abstract

Background

The management of patients with lung cancer has improved recently, and many of them will require admission to the medical intensive care unit (MICU). The aim of this study was to examine the clinical characteristics and to identify risk factors for mortality in patients with lung cancer admitted to the MICU.

Methods

We conducted retrospective analysis on 88 patients with lung cancer admitted to the MICU between April 2004 and March 2008.

Results

Of the 88 patients (mean age, 66 years), 71 patients (80.7%) had non-small cell lung cancer and 17 patients (19.3%) had small cell lung cancer. Distant metastasis were present in 79 patients (89.8%). The main reasons for MICU admission were acute respiratory failure (77.3%), sepsis (11.4%), and central nervous system dysfunction (4.5%). Mechanical ventilation was used in 54 patients (61.4%). Acute Physiology and Chronic Health Evaluation (APACHE) II score, length of MICU stay, need for mechanical ventilation, source of MICU admission were correlated with MICU mortality. The type of lung cancer and metastasis were not predictive factors of death in MICU.

Conclusion

Most common reason for ICU admission was acute respiratory failure. Mortality rate of lung cancer patients admitted to the MICU was 65.9%. APACHE II score, length of ICU stay, need for mechanical ventilation, source of MICU admission were predicted factors of death in the MICU.

Figures and Tables

Table 1
Baseline characteristics of the patients
trd-66-27-i001

Values are expressed as number (percentage) unless otherwise indicated.

SD: standard deviation; COPD: chronic obstructive pulmonary disease.

Table 2
Intensive care unit course
trd-66-27-i002

Values are expressed as number (percentage) unless otherwise indicated.

APACHE: acute physiology and chronic health evaluation; SD: standard deviation; ICU: intensive care unit; CNS: central nervous system.

Table 3
Pathologic type of patients
trd-66-27-i003

Values are expressed as number (percentage) unless otherwise indicated.

NSCLC: non small cell lung cancer.

Table 4
Treatment option of patients
trd-66-27-i004

Values are expressed as number (percentage) unless otherwise indicated.

*Treatment option which was used more than 2 modalities.

Table 5
Predictive factors of death
trd-66-27-i005

Values are expressed as number (percentage) unless otherwise indicated.

APACHE: acute physiology and chronic health evaluation; ICU: intensive care unit; ER: emergency room.

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