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Ko, Song, Shin, Kim, Kim, Han, Lee, Choi, and Kim: A Case of the Minimal Change Nephropathy Associated with Small Cell Lung Cancer
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2008; 65(1): 37-40.

Published online: 31 July 2008

DOI: https://doi.org/10.4046/trd.2008.65.1.37

A Case of the Minimal Change Nephropathy Associated with Small Cell Lung Cancer

Kwang Il Ko, M.D.1, Min Keun Song, M.D.1, Dong Yeob Shin, M.D.1, Dong Hyun Kim, M.D.1, Chan Ho Kim, M.D.1, Chang Hoon Han, M.D.1, Sun Min Lee, M.D.1, Yoon Jung Choi, M.D.2, Chong Ju Kim, M.D.1

1Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

2Department of Pathology, National Health Insurance Corporation Ilsan Hospital, Goyang, Korea.

Address for correspondence: Chong Ju Kim, M.D. Department of Internal Medicine, National Health Insurance Corporation Ilsan Hospital, 1232, Baekseok-dong, Ilsandong-gu, Goyang 410-719, Korea. Phone: 82-31-900-0237, Fax: 82-31-900-0343, kom2d@netsgo.com

Received 9 May 2008       Accepted 17 June 2008

Copyright © 2008 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Nephrotic syndrome is a relatively rare complication of malignancy. A few cases of nephrotic syndrome accompanying Hodgkin's disease, non-Hodgkin lymphoma, leukemia and other malignancies have been reported since the first case of the nephrotic syndrome associated with extrarenal malignancy was reported in 1922. Hodgkin's disease and solid tumors are known to be the most common malignancies accompanying nephrotic syndrome. The pathologic findings of kidney in patients with Hodgkin's disease commonly show minimal change nephropathy. Membranous glomerulonephropathy is the most common pathologic feature in patients with solid tumors. Although membranous glomerulonephropathy related to small cell lung cancer has rarely been reported in Korea, minimal change nephropathy accompanying small cell lung cancer has never been reported. We present here a case of a 70 year-old male with minimal change nephropathy that was related to small cell lung cancer. We detected small cell lung cancer during the diagnosis work-up of nephrotic syndrome. We suggest that nephrotic syndrome can be a manifestation of underlying malignancy.

Keywords: Small cell lung cancer, Minimal change nephropathy, Nephrotic syndrome

Figures and Tables

Figure 1
Bronchoscopy shows a small mass obstructing LLL superior segmental bronchus.
trd-65-37-g001
Figure 2
(A) Kidney: LM: The glomeruli appear normal. The interstitium shows focal mononuclear cell infiltration and edema (H&E stain, ×200). (B) Kidney: EM: The glomerular architecture is intact but the foot processes are diffusely effaced.
trd-65-37-g002

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