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Roh, Um, Choi, Kim, Choi, Lee, Son, and Yang: Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2008; 65(2): 105-109.

Published online: 31 August 2008

DOI: https://doi.org/10.4046/trd.2008.65.2.105

Prognostic Significance of Fascin Expression in Stage I Non-small Cell Lung Cancer

Mee-Sook Roh, M.D.5, Su-Jung Um, M.D.1, Youngmin Choi, M.D.2, Ki-Nam Kim, M.D.3, Pil Jo Choi, M.D.4, Soo-Keol Lee, M.D.1, Choonhee Son, M.D.1, Dookyung Yang, M.D.1

1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

2Department of Radiation Oncology, Dong-A University College of Medicine, Busan, Korea.

3Department of Radiology, Dong-A University College of Medicine, Busan, Korea.

4Department of Thoracic Surgery, Dong-A University College of Medicine, Busan, Korea.

5Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

Address for correspondence: Dookyung Yang, M.D. Department of Internal Medicine, Dong-A University College of Medicine, 1, Dongdaisin-dong 3-ga, Seo-gu, Busan 602-714, Korea. Phone: 82-51-240-2623, Fax: 82-51-242-5852, imyang1@yahoo.com

Received 2 July 2008       Accepted 28 July 2008

Copyright © 2008 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Fascin is an actin-bundling protein that plays an important role in cellular motility. Fascin is normally expressed in the neuronal and mesenchymal cells and its expression is low or absent in the epithelia. However, an overexpression of fascin has been linked to the invasive behavior of some neoplasms such as breast, stomach and ovarian tumors. In this study, we evaluated the expression of fascin and its prognostic significance in stage I non-small cell lung cancer (NSCLC).

Methods

Immunohistochemical staining for fascin was performed on the paraffin-embeded tissue sections of 81 cases of resected NSCLC. Staining of more than 5% of the tumor cells was recorded as positive immunoreactivity.

Results

Fascin expression was seen in 73% (59/81) of the cases and this was more frequently seen in squamous cell carcinoma than in adenocarcinoma (93% vs 42%). There were no significant correlations of fascin immunoreactivity with tumor recurrence and overall survival.

Conclusion

The expression rate of fascin was relatively high in NSCLC, but this was without prognostic significance. The exact clinical role of fascin should be defined through further investigations.

Keywords: Fascin, Lung cancer, Prognosis

Figures and Tables

Figure 1
Immunohistochemical stainings for fascin in non-small cell lung cancer. (A) Negative fascin expression (×100). (B) Positive fascin expression (×100).
trd-65-105-g001
Figure 2
Disease-free survival and overall survival curve according to the expression of fascin in stage I non-small cell lung cancer.
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Table 1
The relationship between clinicopathologic variables and the expression of fascin
trd-65-105-i001

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