Journal List > Tuberc Respir Dis > v.64(5) > 1001233

TOOLS
Huh, Lee, Koo, Shin, Um, Yang, Lee, Son, Roh, Kim, Lee, and Choi: A Case of Bronchiectasis with High Serum CA19-9
Case Report
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2008; 64(5): 383-386.

Published online: 31 May 2008

DOI: https://doi.org/10.4046/trd.2008.64.5.383

A Case of Bronchiectasis with High Serum CA19-9

Jung Hun Huh, M.D.1, Su Mi Lee, M.D.1, Tae Hyoung Koo, M.D.1, Bong Chul Shin, M.D.1, Soo Jung Um, M.D.1, Doo Kyung Yang, M.D.1, Soo-Keol Lee, M.D.1, Choonhee Son, M.D.1, Mee Sook Roh, M.D.2, Ki Nam Kim, M.D.3, Ki Nam Lee, M.D.3, Pil Jo Choi, M.D.4

1Department of Internal Medicine, Dong-A University College of Medicine, Busan, Korea.

2Department of Pathology, Dong-A University College of Medicine, Busan, Korea.

3Department of Radiology, Dong-A University College of Medicine, Busan, Korea.

4Department of Thoracic and Cardiovascular Surgery, Dong-A University College of Medicine, Busan, Korea.

Address for correspondence: Choonhee Son, M.D. Department of Internal Medicine, Dong-A University College of Medicine, 1, Dongdaesin-dong, Seo-gu, Busan 602-714, Korea. Phone: 82-51-240-2874, Fax: 82-51-242-5852, son30243@hanmail.net

Received 1 April 2008       Accepted 9 May 2008

Copyright © 2008 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

An elevated serum CA19-9 level is an indication of pancreatic and biliary tract cancer. However, it has recently become known that nonmalignant gastrointestinal diseases and a variety of nonmalignant respiratory diseases, such as idiopathic interstial pneumonia, collagen vascular disease associated lung diseases, diffuse panbronchiolitis and bronchiectasis, can also show an elevated serum CA19-9 level. We recently encountered a case of bronchiectasis with persistently elevated serum CA19-9, but without any evidence of malignant disease in endoscopic retrograde pancreatocholangiography, abdominal computed tomography, and positron emission tomography. After serial follow-up of 3 years and 10 months, there was still no evidence of cancer. It is believed that the elevated serum CA19-9 level was due to bronchiectasis. An elevated serum CA19-9 level should be interpreted carefully with the patients' clinical condition.

Keywords: CA19-9, Bronchiectasis, Benign

Figures and Tables

Figure 1
Abdominal computed tomography scan showed normal pancreas without tumor.
trd-64-383-g001
Figure 2
Chest computed tomography showed diffuse hazziness along the bronchial tree (A) and fibrostenotic right middle lobe and traction bronchiectasis (B).
trd-64-383-g002

References

1. Plebani M, Basso D, Panozzo MP, Fogar P, Del Favero G, Naccarato R. Tumor markers in the diagnosis, monitoring and therapy of pancreatic cancer: state of the art. Int J Biol Markers. 1995. 10:189–199.
2. Levy C, Lymp J, Angulo P, Gores GJ, Larusso N, Lindor K. The value of serum CA19-9 in predicting cholangiocarcinomas in patients with primary sclerosing cholangitis. Dig Dis Sci. 2005. 50:1734–1740.
3. Shimizu Y, Hamada T, Tanaka Y, Sasaki A, Nemoto T. Colonization of CA19-9 and KL-6 to epithelial cells in dilated bronchioles in a patient with idiopathic pulmonary fibrosis complicated by diffuse alveolar damage. Respirology. 2002. 7:281–284.
4. Mukae H, Hirota M, Kohno S, Komori K, Fukushima K, Hiratani K, et al. Elevation of tumor-associated carbohydrate antigens in patients with diffuse panbronchiolitis. Am Rev Respir Dis. 1993. 148:744–751.
5. Ishiura Y, Fujimura M, Minami S, Ueda A, Iwata M, Watanabe K, et al. Increased CA19-9 level in serum and bronchoalveolar lavage fluid from a patient with pulmonary tuberculosis. Nihon Kyobu Shikkan Gakkai Zasshi. 1996. 34:477–481.
6. Shimizu Y, Hamada T, Tanaka Y, Sasaki A, Nemoto T. Colocalization of CA19-9 and KL-6 to epithelial cells in dilated bronchioles in a patient with idiopathic pulmonary fibrosis complicated by diffuse laveolar damage. Respirology. 2002. 7:281–284.
7. Kodama T, Satoh H, Ishikawa H, Ohtsuka M. Serum levels of CA19-9 in patients with nonmalignant respiratory diseases. J Clin Lab Anal. 2007. 21:103–106.
TOOLS
Similar articles