Journal List > Tuberc Respir Dis > v.64(3) > 1001204

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Kim, Lee, Kim, Kang, Lee, Kim, Lee, Kim, Ahn, Kwon, Kim, Kim, Moon, Song, Park, Moon, and Wang: Prognostic Value of Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF) Expression in Resected Non-small Cell Lung Cancer
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2008; 64(3): 200-205.

Published online: 31 March 2008

DOI: https://doi.org/10.4046/trd.2008.64.3.200

Prognostic Value of Vascular Endothelial Growth Factor (VEGF) and Basic Fibroblast Growth Factor (bFGF) Expression in Resected Non-small Cell Lung Cancer

Seung Joon Kim, M.D.1, Jung Mi Lee1, Jin Sook Kim1, Ji Young Kang, M.D.1, Sang Hak Lee, M.D.1, Seok Chan Kim, M.D.1, Sook Young Lee, M.D.1, Chi Hong Kim, M.D.1, Joong Hyun Ahn, M.D.1, Soon Seog Kwon, M.D.1, Young Kyoon Kim, M.D.1, Kwan Hyoung Kim, M.D.1, Hwa Sik Moon, M.D.1, Jeong Sup Song, M.D.1, Sung Hak Park, M.D.1, Seok Hwan Moon, M.D.2, Yeong Pil Wang, M.D.2

1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul, Korea.

2Department of Thoracic and Cardiovascular Surgery, The Catholic University of Korea College of Medicine, Seoul, Korea.

Address for correspondence: Young Kyoon Kim, M.D. Department of Internal Medicine, Kangnam St. Mary's Hospital, 505, Banpodong, Seocho-gu, Seoul 137-040, Korea. Phone: 82-2-590-2756, Fax: 82-2-599-3589, youngkim@catholic.ac.kr

Received 15 November 2007       Accepted 4 February 2008

Copyright © 2008 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Tumor angiogenesis plays an important role in tumor growth, maintenance and metastatic potential. Tumor tissue produces many types of angiogenic growth factors. Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) have both been implicated to have roles in tumor angiogenesis. In this study, the expression of tissue VEGF and bFGF from non-small cell lung cancer (NSCLC) patients were analyzed.

Methods

We retrospectively investigated 35 patients with a histologically confirmed adenocarcinoma or squamous cell carcinoma of the lung, where the primary curative approach was surgery. An ELISA was employed to determine the expression of VEGF and bFGF in extracts prepared from 35 frozen tissue samples taken from the cancer patients.

Results

VEGF and bFGF concentrations were significantly increased in lung cancer tissue as compared with control (non-cancerous) tissue. The VEGF concentration was significantly increased in T2 and T3 cancers as compared with T1 cancer. Expression of VEGF was increased in node-positive lung cancer tissue as compared with node-negative lung cancer tissue (p=0.06). VEGF and bFGF expression were not directly related to the stage of lung cancer and patient survival.

Conclusion

Expression of VEGF and bFGF were increased in lung cancer tissue, and the expression of VEGF concentration in lung cancer tissue was more likely related with tumor size and the presence of a lymph node metastasis than the expression of bFGF. However, in this study, expression of both VEGF and bFGF in tissue were not associated with patient prognosis.

Keywords: VEGF, bFGF, Angiogenesis, Lung cancer, Prognosis

Figures and Tables

Figure 1
VEGF and bFGF concentrations in control and lung cancer tissue. Compared with control tissue, lung cancer tissue showed significantly increased VEGF and bFGF levels. *Significant difference between control and lung cancer tissue (p<0.01), †Significant difference between control and lung cancer tissue (p<0.05).
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Figure 2
VEGF and bFGF concentrations in lung cancer tissue according to T stage. Compared with T1, T2+T3 showed significantly increased VEGF level in lung cancer tissue. *Significant difference between T1 and T2+T3 (p<0.05).
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Figure 3
VEGF and bFGF concentrations in lung cancer tissue according to N stage. Compared with node negative, node positive showed increased tendency of VEGF level in lung cancer tissue. *Increased tendency in node positive lung cancer tissue compared with node negative lung cancer tissue (p=0.06).
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Figure 4
VEGF and bFGF concentrations in lung cancer tissue according to pathological stage. There was no significant difference according to pathological stage.
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Figure 5
Kaplan-Meier survival curves of non-small cell lung cancer patients after curative surgery according to the median value of VEGF and bFGF concentrations.
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Table 1
The clinicopathological factors of the 35 patients with non-small cell lung cancer
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