Journal List > Tuberc Respir Dis > v.64(3) > 1001202

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Jeon, Shin, Kang, Sung, Kweon, Shin, Kim, Lee, and Park: Trend of Multidrug and Extensively Drug Resistant Tuberculosis in a Tuberculosis Referral Hospital, 2001~2005
Original Article
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2008; 64(3): 187-193.

Published online: 31 March 2008

DOI: https://doi.org/10.4046/trd.2008.64.3.187

Trend of Multidrug and Extensively Drug Resistant Tuberculosis in a Tuberculosis Referral Hospital, 2001~2005

Doosoo Jeon, M.D.1, Dongok Shin, R.N.1, 2, Hyungseok Kang, M.D.1, 2, Nackmoon Sung, Ph.D.1, 2, Kyungsoon Kweon, R.N.1, Eun Shin, R.N.1, Kyungsoon Kim, R.N.1, Myunghee Lee, R.N.1, Seungkyu Park, M.D., Ph.D.1, 2

1National Masan Tuberculosis Hospital, Masan, Korea.

2International Tuberculosis Research Center, Masan, Korea.

Address for correspondence: Seungkyu Park, M.D., Ph.D. National Masan Tuberculosis Hospital, 486, Gapo-dong, Masan 631-710, Korea. Phone: 82-55-249-3786, Fax: 82-55-246-1162, sooli10kr@yahoo.co.kr

Received 15 January 2008       Accepted 12 February 2008

Copyright © 2008 The Korean Academy of Tuberculosis and Respiratory Diseases

Abstract

Background

Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant tuberculosis (XDR-TB) are serious threats to worldwide tuberculosis control, but the national burden and the trends of infectious spread are largely unknown.

Methods

We retrospectively reviewed the results of drug sensitivity tests and medical records of patients that were diagnosed with culture-confirmed pulmonary tuberculosis and were admitted to the National Masan Tuberculosis Hospital between 2001 and 2005.

Results

From 2001 to 2005, the proportion of MDR-TB among new cases was 9.2%, 13.8%, 16.9%, 23% and 27.0% in 2001, 2002, 2003, 2004 and 2005, respectively, and the proportion of MDR-TB among previously treated cases was 58.5%, 60.2%, 62.7%, 61.7% and 71.3% in 2001, 2002, 2003, 2004 and 2005, respectively. A significant increasing trend could be discerned for MDR-TB among both new and previously treated cases (p<0.001, p=0.002 for trend, respectively). The proportion of XDR-TB among new cases was 0%, 2.3%, 3.1%, 2.5% and 6.3% in 2001, 2002, 2003, 2004 and 2005, respectively, and the proportion of XDR-TB among previously treated cases was 9.1%, 15.7%, 17.3%, 19.9% and 19.1% in 2001, 2002, 2003, 2004 and 2005, respectively. A significant increasing trend could be discerned for XDR-TB among both new and previously treated cases (p=0.005, p<0.001 for trend, respectively).

Conclusion

Both MDR-B and XDR-TB were gradually increased among both new and previously treated cases. Integrated national surveillance, including the public and private sectors, will be needed to estimate the exact status of antituberculous drug resistance.

Keywords: Tuberculosis, Multidrug resistance, Extensively drug-resistant tuberculosis

Figures and Tables

Figure 1
Trend of multi-drug resistant tuberculosis, 2001~2005.
trd-64-187-g001
Figure 2
Trend of extensively resistant tuberculosis, 2001~2005.
trd-64-187-g002
Table 1
Characteristics of the study subjects hospitalized in National Masan Tuberculosis Hospital (NMTH)
trd-64-187-i001

*Mean±SD (range), †Gyeongsangnam-do and Busan.

Table 2
Anti-tuberculosis drug susceptibility of M. tuberculosis isolated from new cases, 2001~2005
trd-64-187-i002

MDR: multi-drug resistant tuberculosis; XDR: extensively resistant tuberculosis.

Table 3
Anti-tuberculosis drug susceptibility of M. tuberculosis isolated from previously treated cases, 2001~2005
trd-64-187-i003

MDR: multi-drug resistant tuberculosis; XDR: extensively resistant tuberculosis.

Table 4
The proportion of multi-drug resistant tuberculosis and extensively resistant tuberculosis among total cases, 2001~2005
trd-64-187-i004

MDR: multi-drug resistant tuberculosis; XDR: extensively resistant tuberculosis.

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