Abstract
Primary pulmonary artery sarcoma is a rare malignant tumor arising from the pulmonary artery. Diagnosis of primary pulmonary artery sarcoma is quite difficult and the conditon is often misdiagnosed as a more common disease, such as a pulmonary embolism. PET can help in diagnosing a pulmonary artery sarcoma due to the increased uptake of 18F-FDG in the area of the tumor. However, the poor anatomic resolution of PET has limited its clinical applications in pulmonary vascular disease. The recently developed PET/CT is the fusion of PET and CT that improves the anatomical resolution of PET. We report a case of a primary pulmonary artery sarcoma mimicking a pulmonary embolism that was diagnosed with PET/CT and confirmed with a surgical resection.
References
1. Hoffmeier A, Semik M, Fallenberg EM, Scheld HH. Leiomyosarcoma of pulmonary artery: a diagnostic chameleon. Eur J Cardiothorac Surg. 2001. 20:1049–1051.
2. Britton PD. Primary pulmonary artery sarcoma:a report of two case, with special emphasis on the diagnostic problems. Clin Radiol. 1990. 41:92–94.
3. Park K, Lee JH, Kang JK, Kim HO, Jo KH, Wang YP. Surgical treatment of pulmonary artery sarcoma:one case report. Korean J Thorac Cardiovasc Surg. 2004. 37:597–600.
4. Eary JF, Mankoff DA. Tumor metabolic rates in sarcoma using FDG PET. J Nucl Med. 1998. 39:250–254.
5. Thurer RL, Torsen A, Parker JA, Karp DD. FDG imaging of a pulmonary artery sarcoma. Ann Thorac Surg. 2000. 70:1414–1415.
6. Iagaru A, Chawla S, Menendez L, Conti PS. 18F-FDG PET and PET/CT for detection of pulmonary metastases from musculoskeletal sarcomas. Nucl Med Commun. 2006. 27:795–802.
7. Bryant AS, Cerfolio RJ. The maximum standardized uptake values on integrated FDG-PET/CT is useful in differentiating benign from malignant pulmonary nodules. Ann Thorac Surg. 2006. 82:1016–1020.
8. Cox JE, Chiles C, Aquino SL, Savage P, Oaks T. Pulmonary artery sarcomas: a review of clinical and radiologic features. J Comput Assist Tomogr. 1997. 21:750–755.
9. Baker PB, Goodwin RA. Pulmonary artery sarcoma. Arch Pathol Lab Med. 1985. 109:35–39.
10. Krüger I, Borowski A, Horst M, de Vive ER, Theissen P, Gross-Fengels W. Symptoms, diagnosis, and therapy of primary sarcoma of the pulmonary artery. Thorac Cardiovasc Sug. 1990. 38:91–95.
11. Kim JG, Kim KM, Han JH, Lee KS. Surgical resection of primary sarcoma of pulmonary artery clinically suspected of carcinoid. Korean J Thorac Cardiovasc Surg. 2000. 33:195–198.
12. Flier JS, Mueckler MM, Usher P, Lodish HF. Elevated level of glucose transporter and transporter messenger RNA are induced by ras or src oncogenes. Science. 1987. 235:1492–1495.
13. Monakhov NK, Neistadt EL, Shavlovskil MM, Shvartsman AL, Neifakh SA. Physicochemical properties and isoenzyme composition of hexokinase from normal and malignant human tissues. J Natl Cancer Inst. 1978. 61:27–34.
14. Bacha EA, Wright CD, Grillo HC, Wain JC, Moncure A, Keel SB, et al. Surgical treatment of primary pulmonary sarcomas. Eur J Cardiothorac Surg. 1999. 15:456–460.