Journal List > Tuberc Respir Dis > v.62(3) > 1001060

TOOLS
Kim, Jung, and Jung: Photodynamic Therapy(PDT) in Lung Cancer
Review
Tuberculosis and Respiratory Diseases

Tuberculosis and Respiratory Diseases 2007; 62(3): 175-183.

Published online: 31 March 2007

DOI: https://doi.org/10.4046/trd.2007.62.3.175

Photodynamic Therapy(PDT) in Lung Cancer

Ju Ock Kim, M.D., Mi Kyoung Jung, M.D., Sung Soo Jung, M.D.

Department of Internal Medicine & Research Institite for Medical Science, College of Medicine, Chungnam National University, Daejeon, Korea.

Address for correspondence: Ju-Ock Kim, M.D. Department of Internal Medicine, Chungnam National University Hospital, 640 Dae-Sa-dong, Chung-gu, Taejeon, Korea. Phone: 82-42-280-7158, Fax: 82-42-257-5753, jokim@cnu.ac.kr

Copyright © 2007 The Korean Academy of Tuberculosis and Respiratory Diseases

Figures and Tables

Table 1
Regulatory status of some common PDT photosensitizers
trd-62-175-i001

*Under clinical trials have different names: LS11 or Litx; PDT: photodynamic therapy.

Table 2
Common light delivery modes
trd-62-175-i002
Table 3
Photodynamic therapy (PDT) details of 12 articles (636 patients) concerned with advanced stage lung cancer
trd-62-175-i003

A: advance disease cases; E: early disease cases; YAG: neodynium yttrium aluminium garnet laser therapy; PDT: photodynamic therapy; HPD: haematoporphyrin derivative; PhF: Photofrin; DHE: dihaematoporphyrin ether; ALA: 5-aminolevulinic acid; SCLC: small-cell lung cancer; CR: complete remission; PR: partial remission; EBR: external beam radiotherapy; RT: randomised trial; RMCT: randomised multicentre trial; PS: performance status; O2 oxygen.

*article with mix of early and advanced cases.

Table 4
Photodynamic therapy (PDT) details of 12 articles (517 patients) concerned with early stage lung cancer
trd-62-175-i004

E: early disease cases; A: advance disease cases; YAG: neodynium yttrium aluminium garnet laser therapy; EC: electrocautery; HPD: haematoporphyrin derivative; PhF: photofrin; pt: patient; GA: general anaesthetic; CR: complete remission; SCLC: small cell lung cancer; Ca: cancer; TIS: tumour situ; EBR: external beam radiotherapy; PR: partial remission; PDT: photodynamic therapy; RT: randomised trial.

*article with mix of early and advanced cases.

†patient died.

References

1. Moghissi K, Dixon K, Thorpe JAC. A method of video-assisted thoracoscopic photodynamic therapy (VAT-PDT). Interact Cardiovasc Thoracic Surg. 2003. 2:373–375.
2. Kato H. Photodynamic therapy for lung cancer: a review of 19 years experience. J Photo Chem Photobiol B Biol. 1998. 42:96–99.
3. Balchum OJ, Doiron DR, Huth GC. PDT of endobronchial lung cancer employing the photodynamic action of haematoporphiria derivatives. Lasers Surg Med. 1984. 14:13–30.
4. Lam S, Muller NL, Miller RR, Kostashuk EC, Szasz IJ, LeRiche JC, et al. Predicting the response of obstructive endobronchial tumours to PDT. Cancer. 1986. 58:2298–2306.
5. Lam S, Kostashuk EC, Coy EP, Laukkanen E, LeRiche JC, Mueller HA, et al. A randomised study of the safety and efficacy of photodynamic therapy using photofrin II combined with palliative radiotherapy versus palliative radiotherapy alone in patients with inoperable obstructive non-small cell bronchogenic carcinoma. Photochem Photobiol. 1987. 46:893–897.
6. Edell ES, Cortese DA. Bronchoscopic phototherapy with hematoporphyrin derivative for treatment of localized bronchogenic carcinoma. A 5-year experience. Mayo Clin Proc. 1987. 14:62–68.
7. LoCicero J, Metzdorff M, Almgren C. Photodynamic therapy in the palliation of late stage obstructing non-small cell lung cancer. Chest. 1990. 98:97–100.
8. Ono R, Ikeda S, Suemasu K. Hematoporphyrin derivative photodynamic therapy in roentgenographically occult carcinoma of the tracheobronchial tree. Cancer. 1992. 69:1696–1701.
9. Edell ES, Cortese DA. Photodynamic therapy in the management of early superficial squamous cell carcinoma as an alternative to surgical resection. Chest. 1992. 102:1319–1322.
10. Furuse K, Fukuoka M, Kato H, Horai T, Kubota K, Kodama N, et al. The Japan Lung Cancer Photodynamic Therapy Study Group. A prospective phase II study on photodynamic therapy with photofrin II for centrally located early-stage lung cancer. J Clin Oncol. 1993. 11:1852–1857.
11. Moghissi K, Dixon K, Parsons RJ. Controlled trial of NdYAG laser versus photodynamic therapy for advanced malignant bronchial obstruction. Laser Med Sci. 1993. 8:269–273.
12. Imamura S, Kusunoki Y, Takifuji N, Kudo S, Matsui K, Masuda N, et al. Photodynamic therapy and/or external beam radiation therapy for roentgenologically occult lung cancer. Cancer. 1994. 73:1608–1614.
13. Lam S. Photodynamic therapy of lung cancer. Semin Oncol. 1994. 21:15–19.
14. Sutedja G, Lam S, LeRiche JC, Postmus PE. Response and pattern of failure after photodynamic therapy for intraluminal stage I lung cancer. J Bronchol. 1994. 1:295–298.
15. Freitag L, Korupp A, Itzigehl I, Dankwart F, Tekolf E, Reichle G, et al. Experiences with fluorescence diagnosis and photodynamic therapy in a multimodality therapy concept of operated, recurrent bronchial carcinoma. Pneumologie. 1996. 50:693–699.
16. Cortese DA, Edell ES, Kinsey JH. Photodynamic therapy for early stage squamous cell carcinoma of the lung. Mayo Clin Proc. 1997. 72:595–602.
17. McCaughan JS Jr, William TE. Photodynamic therapy for endobronchial malignant disease: a prospective 14 year study. J Thorac Cardiovascular Surg. 1997. 114:940–947.
18. Moghissi K, Dixon K, Hudson E, Stringer M, Brown S. Endoscopic laser therapy in malignant tracheobronchial obstruction using sequential NdYAG laser and photodynamic therapy. Thorax. 1997. 52:281–283.
19. Weiman TJ, Diaz-Jimenez JP, Moghissi Kl. Photodynamic therapy with Photofrin is effective in the palliation of obstructive endobronchial lung cancer : results of two randomised trials [abstract]. Proceedings of the 34th annual meeting of the American Society of Clinical Oncology. 16-9 May 1998; Los Angeles, CA, USA.
20. Lam S, Haussinger K, Leroy M, Sutedja T, Huber RM. Photodynamic therapy (PDT) with photofrin, a treatment with curative potential for early-stage superficial lung cancer [abstract]. Proceedings of the 34th annual meeting of the American Society of Clinical Oncology. 16-9 May 1998; Los Angeles, CA, USA.
21. Diaz-Jimenez JP, Martinez-Ballarin JE, Llunell A, Farrero E, Rodriguez A, Castro MJ. Efficacy and safety of photodynamic therapy versus Nd-YAG laser resection in NSCLC with airway obstruction. Eur Respir J. 1999. 14:800–805.
22. Moghissi K, Dixon K, Stringer M, Freeman T, Thorpe A, Brown S. The place of bronchoscopic photodynamic therapy in advanced unresectable lung cancer: experience in 100 cases. Eur J Cardiothorac Surg. 1999. 15:15–16.
23. Patelli M, Lazzari Agli L, Poletti V, Falcone F. Photodynamic laser therapy for the treatment of early-stage bronchogenic carcinoma. Monaldi Arch Chest Dis. 1999. 54:315–318.
24. Van Boxem AJM, Westerga J, Wenmans BJW, Postmus PE, Sutedja G. Photodynamic Therapy, NdYAG laser and electro cautery for treating early stage intraluminal cancer: which to choose. Lung Cancer. 2001. 31:31–36.
25. Maier A, Tomaselli F, Matzi V, Woltsche M, Anegg U, Fell B, et al. Comparison of 5-aminolaevulinic acid and prophyrin photosensitization for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study. Lasers Surg Med. 2002. 30:12–17.
26. Kato H, Harada M, Ichinose S, Usuda J, Tsuchida T, Okunaka T. Photodynamic therapy of lung cancer: experience of the Tokyo Medical University. Photodiag Photodyn Therapy. 2004. 1:49–55.
27. Lam S, Kennedy T, Unger M, Miller YE, Gelmont D, Rusch V, et al. Localization of bronchial intraepithelial neoplastic lesions by fluorescence bronchoscopy. Chest. 1998. 113:696–702.
28. Pasic A, Vonk-Noordegraaf A, Risse EKJ. Multiple suspicious lesions detected by autofluorescence bronchoscopy predict malignant development in the bronchial mucosa in high risk patients. Lung Cancer. 2003. 41:295–301.
29. Herth F, Ernst A, Schulz M, Becker H. Endobronchial ultrasonography reliably differentiates between airway infiltration and compression by tumour. Chest. 2003. 123:458–462.
30. Takahashi H, Sagawa M, Sato M, Sakurada A, Endo C, Ishida I, et al. A prospective evaluation of transbronchial ultrasonography for assessment of depth of invasion in early bronchogenic squamous cell carcinoma. Lung Cancer. 2003. 42:43–49.
31. Moghissi K, Bond MG, Sambrook RJ, Stephens RJ, Hopwood P, Girling DJ. Treatment of endotracheal or endobronchial obstruction by non-small cell lung cancer: lack of patients in an MRC randomised trial leaves key questions unanswered. Clin Oncol. 1999. 11:179–183.
32. Mathur PN, Edell E, Sutedja T, Vergnon JM. American College of Chest Physicians. Treatment of early stage non-small cell lung cancer. Chest. 2003. 123:1765–1805.
33. Dougherty TJ. An update on photodynamic therapy applications. J Clin Laser Med Surg. 2002. 20:3–7.
34. Dougherty TJ. Activated dye as an antitumour agent. J Natl Cancer Inst. 1974. 52:1333–1336.
35. Radu A, Grosjean P, Fontolliet CH. Photodynamic therapy for 101 early cancer of the upper aerodigestive tract, the esophagus and the bronchi : a single-institution experience. Diagnost Therapeutic Endosc. 1999. 5:145–154.
36. Kato H, Furukawa K, Sato M, Okunaka T, Kusunoki Y, Kawahara M, et al. Phase II clinical study of photodynamic therapy using mono-L-aspartyl chlorin e6 and diode laser for early superficial squamous cell carcinoma of the lung. Lung Cancer. 2003. 42:103–111.
37. Mang TS. Lasers and light sources for PDT: past, present and future. Photodiag Photodyn Therapy. 2004. 1:43–48.
38. Maier A, Tomaselli F, Matzi V, Woltsche M, Anegg U, Fell B, et al. Comparison of 5-aminolevulinic acid and porphyrins photosensitisation for photodynamic therapy of malignant bronchial stenosis: a clinical pilot study. Laser Surg Med. 2002. 30:12–17.
39. Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle D, Mittleman A. Photoradiation therapy for the treatment of malignant tumors. Cancer Res. 1978. 38:2628–2635.
40. Hyata Y, Kato H, Konaka C, Ono J, Takizawa N. Haematoporphyrin in derivative and laser photoradiation in the treatment of lung cancer. Chest. 1982. 81:264–277.
41. Moghissi K, Dixon K. Is bronchoscopic photodynamic therapy a therapeutic option in lung cancer. Eur Resp J. 2003. 22:535–541.
42. Okunaka T, Kato H, Tsutsui H, Ishizumi T, Ichinose S, Kuroiwa Y. Photodynamic therapy for peripheral lung cancer. Lung Cancer. 2004. 43:77–82.
43. Moghissi K. Role of bronchoscopic photodynamic therapy in lung cancer management. Curr Opin Pulm Med. 2004. 10:256–260.
TOOLS
Similar articles